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Editorial
. 2021 Apr;32(4):768-771.
doi: 10.1681/ASN.2021010017. Epub 2021 Mar 4.

Me Or Your Own Eyes: RNA-Seq and the Kidney

David H Ellison  1   2
Affiliations
Editorial

Me Or Your Own Eyes: RNA-Seq and the Kidney

David H Ellison. J Am Soc Nephrol. 2021 Apr.
No abstract available

Keywords: nephron; transcriptional profiling.

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Figures

Figure 1.
Figure 1.
Sites of relative gene expression along the nephron. Ovals emphasize predominant expression sites for components of signaling pathways. Note the preponderance of AngII receptors along the proximal tubule (yellow oval), the expression of KLHL3 and KS-WNK1 along the DCT (blue oval), and the expression of 11 β-hydroxysteroid dehydrogenase 2 along the connecting tubule and cortical collecting duct (red oval). S1–S3, segments of the proximal tubule, L1–L3, segments of the descending limbs, ATL, ascending thin limb; TAL, thick ascending limb; CNT, connecting tubule; CCD, cortical collecting duct; OMCD, outer medullary collecting duct; IMCD, inner medullary collecting duct. Redrawn from https://esbl.nhlbi.nih.gov/MRECA/Nephron/.
See this image and copyright information in PMC

Comment on

References

    1. Chen L, Clark JZ, Nelson JW, Kaissling B, Ellison DH, Knepper MA: Renal-tubule epithelial cell nomenclature for single-cell RNA-sequencing studies [published correction appears in J Am Soc Nephrol 30: 2475, 2019]. J Am Soc Nephrol 30: 1358–1364, 2019 - PMC - PubMed
    1. Chen L, Chou C-L, Knepper MA: A comprehensive map of mRNAs and their isoforms across all 14 renal tubule segments of mouse. J Am Soc Nephrol 32: 897–912, 2021 - PMC - PubMed
    1. Chen L, Chou C-L, Knepper MA: Targeted single-cell RNA-seq identifies minority cell types of kidney distal nephron. J Am Soc Nephrol 32: 886–896, 2021 - PMC - PubMed
    1. Ransick A, Lindström NO, Liu J, Zhu Q, Guo JJ, Alvarado GF, et al. .: Single-cell profiling reveals sex, lineage, and regional diversity in the mouse kidney. Dev Cell 51: 399–413.e7, 2019 - PMC - PubMed
    1. Park J, Shrestha R, Qiu C, Kondo A, Huang S, Werth M, et al. .: Single-cell transcriptomics of the mouse kidney reveals potential cellular targets of kidney disease. Science 360: 758–763, 2018 - PMC - PubMed

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