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. 2021 Mar 26;21(1):139.
doi: 10.1186/s12876-021-01716-6.

The incidence and prevalence of inflammatory bowel disease in UK primary care: a retrospective cohort study of the IQVIA Medical Research Database

Karoline Freeman  1 , Ronan Ryan  2 , Nicholas Parsons  3 , Sian Taylor-Phillips  3 , Brian H Willis  2 , Aileen Clarke  3
Affiliations

The incidence and prevalence of inflammatory bowel disease in UK primary care: a retrospective cohort study of the IQVIA Medical Research Database

Karoline Freeman et al. BMC Gastroenterol. .

Abstract

Background: Our knowledge of the incidence and prevalence of inflammatory bowel disease (IBD) is uncertain. Recent studies reported an increase in prevalence. However, they excluded a high proportion of ambiguous cases from general practice. Estimates are needed to inform health care providers who plan the provision of services for IBD patients. We aimed to estimate the IBD incidence and prevalence in UK general practice.

Methods: We undertook a retrospective cohort study of routine electronic health records from the IQVIA Medical Research Database covering 14 million patients. Adult patients from 2006 to 2016 were included. IBD was defined as an IBD related Read code or record of IBD specific medication. Annual incidence and 12-month period prevalence were calculated.

Results: The prevalence of IBD increased between 2006 and 2016 from 106.2 (95% CI 105.2-107.3) to 142.1 (95% CI 140.7-143.5) IBD cases per 10,000 patients which is a 33.8% increase. Incidence varied across the years. The incidence across the full study period was 69.5 (95% CI 68.6-70.4) per 100,000 person years.

Conclusions: In this large study we found higher estimates of IBD incidence and prevalence than previously reported. Estimates are highly dependent on definitions of disease and previously may have been underestimated.

Keywords: Electronic health care records; Epidemiology; Inflammatory bowel disease; Primary health care.

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Conflict of interest statement

The authors declare: KF is funded by the NIHR through a doctoral research fellowship. AC is supported by the NIHR ARC West Midlands initiative. STP is funded by the NIHR through a career development fellowship (NIHR-CDF-2016-09-018). BHW reports grants from the Medical Research Council. RR and NP have nothing to declare.

Figures

Fig. 1
Fig. 1
Overview of inclusion and exclusion of cases for the analyses of IBD incidence and prevalence
Fig. 2
Fig. 2
12-month period prevalence of IBD per 10,000 adult IMRD population
Fig. 3
Fig. 3
Annual IBD incidence per 100,000 person-years in the adult IMRD population
See this image and copyright information in PMC

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