Conflict of Interest:

Dr. Permaul has nothing to disclose. Dr. Peters reports grants from NIH/NHLBI and grants from Boeringer-Ingelheim, during the conduct of the study; grants from AstraZeneca, Boehringer-Ingelheim, Genentech, GSK, Sanofi-Genzyme-Regeneron, and Teva, outside the submitted work. Mr. Petty has nothing to disclose. Dr. Cardet reports personal fees from AstraZeneca and from Genentech outside the submitted work. Dr. Ly reports grants from Vertex, grants from Gilead, outside the submitted work. Dr. Ramratnam reports grants from AstraZeneca, during the conduct of the study. Dr. Ross reports grants from NHLBI, grants from AstraZeneca, during the conduct of the study; grants and non-financial support from TEVA, non-financial support from GSK, non-financial support from Merck, grants from Flamel, grants from Jazz, grants from AstraZeneca, grants from Boehringer Ingelheim, and grants from Novartis, outside the submitted work. Dr. Fitzpatrick has nothing to disclose. Dr. Israel reports grants from AstraZeneca, non-financial support from GSK, during the conduct of the study; personal fees from AB Science, grants and personal fees from Amgen, grants and personal fees from AstraZeneca, grants and personal fees from Avillion, personal fees from Biometry, personal fees from Equillium, personal fees from Merck, grants and personal fees from Novartis, personal fees from 4D Pharma, personal fees from Pneuma Respiratory, personal fees from PPS Health, personal fees from Regeneron, personal fees from Sanofi Genzyme, personal fees from Sienna Biopharmaceutical, other from Vorso Corp, grants, personal fees and non-financial support from Genentech, personal fees and non-financial support from GSK, personal fees and non-financial support from TEVA, grants from Gossamer Bio, grants and non-financial support from Circassia, non-financial support from Boehringer Ingelheim, outside the submitted work. Dr. Bacharier reports grants from NIH/NIADI, during the conduct of the study; personal fees from GSK, personal fees from Genentech/Novartis, personal fees and non-financial support from Merck, personal fees from DBV Technologies, personal fees and non-financial support from Teva, personal fees and non-financial support from Boehringer Ingelheim, personal fees from AstraZeneca, personal fees from WebMD/Medscape, personal fees from Sanofi/Regeneron, personal fees from Vectura, personal fees from Circassia, outside the submitted work. Dr. Phipatanakul reports other trial support from AstraZeneca, during the conduct of the study; grants and personal fees from Genentech/Novartis, grants and personal fees from Sanofi/Regeneron, other trial support and medications from Merck, other trial support and reagents from Alk-Abello, personal consulting fees from GSK, other trial support and medications from Kaleo, grants from NIH, other trial support and medications from CSL-Behring, outside the submitted work.