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Review
. 2021 Apr;108(4):528-538.
doi: 10.1007/s00223-021-00838-z. Epub 2021 Mar 26.

The Role of Bone Biopsy in the Management of CKD-MBD

Ana Carina Ferreira  1   2 , Martine Cohen-Solal  3   4 , Patrick C D'Haese  5 , Aníbal Ferreira  6   7 ; European Renal Osteodystrophy (EUROD), an initiative of the CKD-MBD working group of the ERA-EDTA
Affiliations
Review

The Role of Bone Biopsy in the Management of CKD-MBD

Ana Carina Ferreira et al. Calcif Tissue Int. 2021 Apr.

Abstract

A bone biopsy is still considered the gold standard for diagnosis of renal osteodystrophy. It allows to measure both static and dynamic parameters of bone remodeling and is the only method able to evaluate mineralization and allows analysis of both cortical and trabecular bone. Although bone volume can be measured indirectly by dual-energy X-ray absorptiometry, mineralization defects, bone metal deposits, cellular number/activity, and even turnover abnormalities are difficult to determine by techniques other than qualitative bone histomorphometry. In this review, we evaluate the role of bone biopsy in the clinical practice.

Keywords: Bone histomorphometry; Dialysis; Renal osteodystrophy.

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References

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