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. 2021 Nov;25(11):3669-3686.
doi: 10.1007/s10461-021-03242-8. Epub 2021 Mar 27.

A Systematic Review of Randomized Controlled Trials of School Based Interventions on Sexual Risk Behaviors and Sexually Transmitted Infections Among Young Adolescents in Sub-Saharan Africa

Nosipho Shangase #  1   2 , Ayesha B M Kharsany #  3   4 , Nonzwakazi P Ntombela  2 , Audrey Pettifor  2 , Lyle R McKinnon  2   5
Affiliations

A Systematic Review of Randomized Controlled Trials of School Based Interventions on Sexual Risk Behaviors and Sexually Transmitted Infections Among Young Adolescents in Sub-Saharan Africa

Nosipho Shangase et al. AIDS Behav. 2021 Nov.

Abstract

Young adolescents in Sub-Saharan Africa (SSA) are at high risk of involvement in sexual risk behaviors; and curable sexually transmitted infections (STI), herpes simplex virus type 2 (HSV-2), human immunodeficiency virus (HIV) and unintended pregnancies remain persistently high in this population. Evidence based strategies are urgently needed to improve these outcomes. The aim of this systematic review was to synthesize the evidence from randomized controlled trials (RCT) to determine whether school-based interventions promote safe sex behaviors, reduce sexual risk behaviors and risk of curable STIs, HSV-2, HIV and unintended pregnancies among young adolescents aged 9-19 years in SSA. Electronic databases were searched for published studies and manual searches were conducted through reviewing of references of cited literature in the English language up to December 2019. Two independent reviewers screened and abstracted the data. We identified 428 articles and data from nine RCTs (N = 14,426 secondary school students) that fulfilled the selection criteria were analysed. Two studies measured pregnancy as an outcome and showed significant declines in unintended pregnancies. Of the five studies that measured HIV/AIDS related-knowledge, condom-use outcomes (normative beliefs, knowledge, and self-efficacy) and attitudes to HIV testing, four showed significant improvements. Of the six studies that measured sexual debut, four reported moderate but non-significant declines and in two studies sexual debut information was either incomplete or unreliable. One study measured curable STIs and found no significant declines; whilst the second study that measured HSV-2 and HIV, no significant declines were observed. This review highlights the need to undertake well-designed research studies to provide evidence on the impact of interventions on curable STIs, HSV-2 and HIV, critical to improving the health of young adolescents.

Keywords: HIV; Interventions; Schools; Sexual risk behaviors; Sexually transmitted infections; Sub-Saharan Africa; Systematic review; Unintended pregnancies; Young adolescents.

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Conflict of interest statement

Conflict of interest

The authors declare that they have no conflict of interest.

Figures

Figure 1
Figure 1
Search strategy and selection of articles for analysis and reported according to PRISMA guidelines
See this image and copyright information in PMC

References

    1. Joint United Nations Programme on HIV/AIDS (UNAIDS). The Gap Report ISBN 978-92-9253-062-4 2014, Available at: http://www.unaids.org/en/media/unaids/contentassets/documents/unaidspubl... Date accessed 05 April 2019.
    1. South African National Department of Health.: The 2015 National Antenatal Sentinel HIV and Syphilis Survey Report, South Africa. 2017, Available at www.health.gov.za/…/2015…/2015…/2015-04-30-08-21-56?…2015…hiv…survey… Date accessed 15 May 2019.
    1. Joint United Nations Programme on HIV/AIDS (UNAIDS). Global AIDS Update, 2016 2016, Available at: http://www.unaids.org/sites/default/files/media_asset/global-AIDS-update... Date accessed 05 April 2019.
    1. United Nations.: The Millennium Development Goals Report 2015. 2015, Available at https://www.un.org/millenniumgoals/2015_MDG_Report/pdf/MDG%202015%20rev%...: Date accessed 04 April 2019.
    1. World Health Organization.: Global health sector strategy on Sexually Transmitted Infections 2016–2021: Towards ending STIs. 2016, Available at: https://www.who.int/reproductivehealth/publications/rtis/ghss-stis/en/: Accessed 4 May 2019.

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