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. 2021 Mar 1;22(3):691-697.
doi: 10.31557/APJCP.2021.22.3.691.

Seizure in Indonesian Glioma Patients: Associated Risk Factors and Impact on Survival

Rahmat Andi Hartanto  1 , Ery Kus Dwianingsih  2 , Andre Stefanus Panggabean  3 , Adiguno Suryo Wicaksono  1 , Kusumo Dananjoyo  3 , Ahmad Asmedi  3 , Rusdy Ghazali Malueka  3
Affiliations

Seizure in Indonesian Glioma Patients: Associated Risk Factors and Impact on Survival

Rahmat Andi Hartanto et al. Asian Pac J Cancer Prev. .

Abstract

Objective: Seizure is commonly found in patients with glioma. This study aimed to find risk factors for seizures in Indonesian patients with glioma. We also sought to determine the association between seizure and survival in this patient population.

Methods: Patients with glioma were enrolled from the Dr. Sardjito General Hospital and other hospitals in Yogyakarta Province, Indonesia. Detailed demographic and clinical data were collected from medical records. DNA extraction and polymerase chain reaction (PCR) were performed to detect IDH1 mutation. Tumor tissue samples were stained by hematoxylin-eosin and classified according to the 2016 World Health Organization (WHO) classification of central nervous system (CNS) tumors. Expression of Ki-67 was detected by immunohistochemistry staining. Survival data were also collected.

Results: In total, 107 patients were included in the analysis. Age, gender, history of smoking, tumor side, tumor grade, Ki-67 expression, and IDH1 mutation were not associated with seizure. Tumors involving the frontal lobe (p=0.037) and oligodendroglioma histology (p=0.031) were associated with the development of seizures in this study. However, multivariate analysis showed that only oligodendrogial histology was associated with seizure [p=0.032, odds ratio (OR) = 4.77, 95% confidence interval (CI) = 1.146-19.822]. Patients with seizures have significantly longer median overall survival than patients without seizures (69.3±25.01 vs. 10.6±6.14 months, respectively, p=0.04).

Conclusion: This study showed that seizure in patients with glioma in Indonesia is associated with frontal lobe location and oligodendroglioma histology. Patients with seizures also have significantly longer overall survival. <br />.

Keywords: Glioma; risk factors; seizure; survival.

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Conflict of interest statement

The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Kaplan-Meier Survival Analysis Demonstrating that Patients with Seizure (Straight Line) had a Significantly Longer Overall Survival (p = 0.04; log-rank Test).
See this image and copyright information in PMC

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