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. 2021 Mar 1;22(3):767-774.
doi: 10.31557/APJCP.2021.22.3.767.

Evaluation of Cortactin and HS1 Genes Expression: New Players in Adult B-Cell Acute Lymphoblastic leukemia

Salah Aref  1 , Mohamed Al Agdar  1 , Ahmed Ramez  2 , Tarek Abou Zeid  3 , Mohamed Sabry  1 , Nada Khaled  1
Affiliations

Evaluation of Cortactin and HS1 Genes Expression: New Players in Adult B-Cell Acute Lymphoblastic leukemia

Salah Aref et al. Asian Pac J Cancer Prev. .

Abstract

Objectives: This study aimed to assess the prognostic value of cortactin and HS1 genes expression in adult B-cell acute lymphoblastic leukemia.

Methods: The study included a cohort of 74 adult B-ALL patients and 76 controls. Cortactin and HS1 genes expression were quantified by real time PCR.

Results: The expression of cortactin and HS1 were significantly higher in B-ALL patients at diagnosis as compared to post induction levels (p.

Keywords: B-ALL, Cortactactin; HS1, Prognosis.

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Figures

Figure 1
Figure 1
Correlation of Cortactin with HS1 Gene Expression in All Studied Cases. A significant positive correlation between the two parameters (R=0.629, p<0.001).
Figure 2a
Figure 2a
Kaplan-Meier Plot of the OS Probability in the High and Low Cortactin Groups
Figure 2b
Figure 2b
Kaplan-Meier Plot of the OS Probability in the High and Low HS1 Groups
Figure 3a
Figure 3a
Comparison of the Cumulative Incidence of Rrelapse (CIR) Curves between the Low and High Cortactin Gene Expressions Groups
Figure 3b
Figure 3b
Comparison of the Cumulative Incidence of Relapse (CIR) Curves between the Low and High HS1 Gene Expression
See this image and copyright information in PMC

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