Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Jun;49(3):533-537.
doi: 10.1007/s15010-021-01605-w. Epub 2021 Mar 27.

Shift in bacterial etiology from the CAPNETZ cohort in patients with community-acquired pneumonia: data over more than a decade

D C W Braeken  1 , A Essig #  2 , M Panning  3 , R Hoerster  4 , M Nawrocki  5 , K Dalhoff  4 , N Suttorp  5   6 , T Welte  5   7   8 , M W Pletz  5   9 , M Witzenrath  5   6 , G G U Rohde  5   8   10 , J Rupp  11   12 ; CAPNETZ- Study Group
Collaborators, Affiliations

Shift in bacterial etiology from the CAPNETZ cohort in patients with community-acquired pneumonia: data over more than a decade

D C W Braeken et al. Infection. 2021 Jun.

Abstract

To determine the most relevant pathogens for CAP in Germany, patients with radiologically confirmed pulmonary infiltrates and at least one clinical sign of lung infection were prospectively recruited within the CAPNETZ cohort from 2004 until 2016. In 990 out of 4.672 patients (21%) receiving complete diagnostics the most prominent change of pathogens was a decrease of S. pneumoniae (58% in 2004 to 37.5% in 2016; p ≤ 0.001, ρ = - 0.148) and an increase of H. influenzae (12.2% to 20.8%; p = 0.001, ρ = 0.104).

Keywords: CAP; Culture; Diagnostics; Pathogens.

PubMed Disclaimer

Conflict of interest statement

No conflict of interest to declare by all authors.

Figures

Fig. 1
Fig. 1
Distribution of bacterial pathogens detected in patients with complete diagnostics within the CAPNETZ cohort from 2004 to 2016. Association of pathogen detection with time was conducted using linear regression analysis by calculating Spearman's correlation coefficient (ρ)
See this image and copyright information in PMC

References

    1. Macfarlane JT, Colville A, Guion A, Macfarlane RM, Rose DH. Prospective study of aetiology and outcome of adult lower-respiratory-tract infections in the community. Lancet. 1993;341(8844):511–514. doi: 10.1016/0140-6736(93)90275-l. - DOI - PubMed
    1. Musher DM, Abers MS, Bartlett JG. Evolving understanding of the causes of pneumonia in adults, with special attention to the role of pneumococcus. Clin Infect Dis. 2017;65(10):1736–1744. doi: 10.1093/cid/cix549. - DOI - PMC - PubMed
    1. Alyacoubi S, Abuowda Y, Albarqouni L, Bottcher B, Elessi K. Inpatient management of community-acquired pneumonia at the European Gaza Hospital: a clinical audit. Lancet. 2018;391(Suppl 2):S40. doi: 10.1016/S0140-6736(18)30406-9. - DOI - PubMed
    1. Uematsu H, Hashimoto H, Iwamoto T, Horiguchi H, Yasunaga H. Impact of guideline-concordant microbiological testing on outcomes of pneumonia. Int J Qual Health Care. 2014;26:100–107. doi: 10.1093/intqhc/mzt078. - DOI - PubMed
    1. Pereira JM, Goncalves-Pereira J, Ribeiro O, Baptista JP, Froes F, Paiva JA. Impact of antibiotic therapy in severe community-acquired pneumonia: data from the infauci study. J Crit Care. 2018;43:183–189. doi: 10.1016/j.jcrc.2017.08.048. - DOI - PubMed

LinkOut - more resources