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. 2021 Mar;49(3):300060521999555.
doi: 10.1177/0300060521999555.

Association of dyslipidaemia with osteoporosis in postmenopausal women

Lingnan Zhang  1 , Qilong Liu  2 , Xianshang Zeng  3 , Wenshan Gao  4 , Yanan Niu  4 , Xiaoyong Ma  4 , Huijun Xie  4 , Xiaozhe Zhou  4 , Weiguang Yu  3 , Guixing Xu  5
Affiliations

Association of dyslipidaemia with osteoporosis in postmenopausal women

Lingnan Zhang et al. J Int Med Res. 2021 Mar.

Abstract

Objective: To assess the association of dyslipidaemia with osteoporosis in postmenopausal women.

Methods: Data from 160 postmenopausal women with newly diagnosed osteoporosis (osteoporosis group) and 156 healthy controls (control group) were retrospectively reviewed from 2016 to 2020. The primary outcomes were laboratory values assessed by a multivariate binary logistic regression model.

Results: Factors that greatly increased the risk of being in the osteoporosis group included high low-density lipoprotein (LDL) and low high-density lipoprotein (HDL) levels. The osteoporosis group had lower HDL and higher LDL levels than the control group. A multivariate binary logistic regression model showed that lower HDL and higher LDL levels were the only variables that were significantly associated with osteoporosis (odds ratio 1.86, 95% confidence interval: 3.66-4.25 and odds ratio 1.47, 95% confidence interval: 1.25-2.74, respectively).

Conclusion: Low HDL and high LDL levels may be associated with the occurrence of osteoporosis in postmenopausal women.

Keywords: Dyslipidaemia; bone mineral density; cholesterol; diabetes; high-density lipoprotein; low-density lipoprotein; osteoporosis.

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Conflict of interest statement

Declaration of conflicting interest: The authors declare that there is no conflict of interest.

Figures

Figure 1.
Figure 1.
Flow diagram showing selection of a cohort of postmenopausal women with newly diagnosed osteoporosis and reasons for exclusion. OS, osteoporosis.
See this image and copyright information in PMC

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