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Review
. 2021 Jun:79:100964.
doi: 10.1016/j.mam.2021.100964. Epub 2021 Mar 26.

The role of O-glycosylation in human disease

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Review

The role of O-glycosylation in human disease

Ana Magalhães et al. Mol Aspects Med. 2021 Jun.

Abstract

O-glycosylation is a highly frequent post-translation modification of proteins, with important functional implications in both physiological and disease contexts. The biosynthesis of O-glycans depends on several layers of regulation of the cellular glycosylation machinery, being organ-, tissue- and cell-specific. This review provides insights on the molecular mechanism underlying O-glycan biosynthesis and modification, and highlights illustrative examples of diseases that are triggered or modulated by aberrant cellular O-glycosylation. Particular relevance is given to genetic disorders of glycosylation, infectious diseases and cancer. Finally, we address the potential of O-glycans and their biosynthetic pathways as targets for novel therapeutic strategies.

Keywords: Cancer; Cellular signaling; Glycan-based therapies; Glycosyltransferases; Infection; O-Glycans.

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