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Review
. 2021 Jul-Aug;23(6-7):104815.
doi: 10.1016/j.micinf.2021.104815. Epub 2021 Mar 26.

Cause or effect? The spatial organization of pathogens and the gut microbiota in disease

Jen Nguyen  1 , Deanna M Pepin  2 , Carolina Tropini  3
Affiliations
Free article
Review

Cause or effect? The spatial organization of pathogens and the gut microbiota in disease

Jen Nguyen et al. Microbes Infect. 2021 Jul-Aug.
Free article

Abstract

The human gut hosts a dense and diverse microbial community, spatially organized in multiple scales of structure. Here, we review how microbial organization differs between health and disease. We describe how changes in spatial organization may induce alterations in gut homeostasis, concluding with a future outlook to reveal causality.

Keywords: Community dynamics; Intestinal mucus; Intestinal pathogenesis; Microbial biogeography; Microbiome.

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