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. 2020 Jul-Sep;11(3):217-222.
doi: 10.4103/ccd.ccd_7_19. Epub 2020 Nov 26.

Different Regenerative Responses of Two Platelet Concentrates in the Treatment of Human Periodontal Infrabony Defects: A Clinico-Radiographic Study

Himani Upadhyay  1 , Hirak S Bhattacharya  1 , Manvi Chandra Agarwal  1 , R G Shiva Manjunath  1 , Ashutosh Agarwal  1 , Himanshu Upadhyay  2
Affiliations

Different Regenerative Responses of Two Platelet Concentrates in the Treatment of Human Periodontal Infrabony Defects: A Clinico-Radiographic Study

Himani Upadhyay et al. Contemp Clin Dent. 2020 Jul-Sep.

Abstract

Background: Platelet concentrates usage in the treatment of intrabony defects has been improved due to advancement of research. Many generation of platelet concentrates were used, but research regarding advanced platelet-rich fibrin (A-PRF) regarding periodontal treatment is scanty.

Aim: The purpose of the study was to evaluate and compare PRF and A-PRF in the treatment of human periodontal infrabony defects (IBDs) both clinically and radiographically.

Materials and methods: Twenty-eight patients having IBDs were divided into Group A (PRF) and Group B (A-PRF). Clinical parameters such as plaque index, gingival index, probing pocket depth (PPD), and clinical attachment level (CAL) were recorded at baseline and 3 and 6 months and radiographic examination at baseline and 6 months were also recorded to evaluate defect fill, resolution, and change in the alveolar crest height. Then, all the data were tabulated in a Microsoft Excel sheet and subjected to statistical analysis. Mean and standard deviations of the clinical and radiographic parameters were calculated, and unpaired t-test was performed to assess intergroup comparison at different time intervals.

Results: Intragroup comparison showed statistically significant improvement in PPD and CAL at 3 and 6 months while statistically significant improvement was observed in mean defect fill and resolution in Group B.

Conclusion: Individually, both the materials have shown promising results. However, statistically, PRF group (Group A) showed better treatment outcome in terms of bone fill and A-PRF group (Group B) in terms of soft tissue healing.

Keywords: Advanced platelet-rich fibrin; infrabony defect; periodontal regeneration; platelet-rich fibrin.

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Conflict of interest statement

There are no conflict of interest.

Figures

Figure 1
Figure 1
(a and b) Depicts pre-operative and post-operative probing pocket depths of group a; (c and d) depicts pre-operative and post-operative probing pocket depths of group b
Figure 2
Figure 2
(a and b) Depicts pre-operative and post-operative intraoral periapical radiographs (iopa) of group a; (c and d) depicts pre-operative and post-operative intraoral periapical radiographs (iopa) of group b
Graph 1
Graph 1
Various clinical parameters at different time periods in both the groups
Graph 2
Graph 2
Various radiographic parameters at different time periods in both the groups
See this image and copyright information in PMC

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