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. 2021 Mar 9:2021:6627531.
doi: 10.1155/2021/6627531. eCollection 2021.

Progression of CIN1/LSIL HPV Persistent of the Cervix: Actual Progression or CIN3 Coexistence

Maria Teresa Bruno  1 , Nazario Cassaro  2 , Francesca Bica  1 , Sara Boemi  1
Affiliations

Progression of CIN1/LSIL HPV Persistent of the Cervix: Actual Progression or CIN3 Coexistence

Maria Teresa Bruno et al. Infect Dis Obstet Gynecol. .

Abstract

Objective: The natural history of the CIN1 lesions is characterized by an elevated rate of spontaneous regression (80%), some authors recognize a capacity to progress to HSIL in 10% of cases, and other authors do not recognize the capacity of progression of LSIL (CIN1). This study was aimed to evaluate the incidence of progression to HSIL (CIN3) in women with a histological diagnosis of LSIL (CIN1). Furthermore, to this end, we studied the histological outcomes of cone specimens collected by the LEEP.

Methods: All the data were retrospectively analyzed. All participants underwent a follow-up of 4 years, during which each woman underwent an HPV test and genotyping, cervical cytological sampling, or biopsy every six months. The endpoint was the histological confirmation of CIN3 lesions in any moment during follow-up.

Results: Progression to CIN3 occurred in 7 cases (1,5%). Analyzing the histological exams of the cones of the 7 cases that progressed to CIN3, we found the coexistence of CIN1 and CIN3 lesions in all cases.

Conclusion: After 4 years of follow-up, only 1.5% (7/475) of the women with LSIL developed CIN3, all within the first two years of follow-up, and were immediately treated. The most likely explanations for "progression" from LSIL to HSIL are (1) actual progression, (2) underdiagnosis of HSIL on initial biopsy, (3) overdiagnosis of HSIL on follow-up biopsy/cone, and (4) CIN3 arose de novo. Analyzing the histological exams of the cones of the 7 cases that progressed to high-grade, we found the coexistence of CIN1 and CIN3 lesions in all cases. Some recent studies have shown that a viral genotype corresponds to different lesions in the same cervix; therefore, CIN1 coexisting with CIN3 does not always indicate progression of CIN1. Other authors have doubted the capacity of LSIL to progress.

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Conflict of interest statement

The authors declare that they have no conflict of interests.

Figures

Figure 1
Figure 1
Flow Chart of the regression, persistence, and progression histological during 4 years of follow-up in the study group.
See this image and copyright information in PMC

References

    1. Darragh T. M., Colgan T. J., Cox J. T., et al. The Lower Anogenital Squamous Terminology Standardization Project for HPV-Associated Lesions: background and consensus recommendations from the College of American Pathologists and the American Society for Colposcopy and Cervical Pathology. Journal of Lower Genital Tract Disease. 2012;16(3):205–242. doi: 10.1097/LGT.0b013e31825c31dd. - DOI - PubMed
    1. Jordan J., Martin-Hirsch P., Arbyn M., et al. European guidelines for clinical management of abnormal cervical cytology, part2. Cytopathology. 2009;20(1):5–16. doi: 10.1111/j.1365-2303.2008.00636.x. - DOI - PubMed
    1. Italian society of colposcopy and cervicovaginal pathology. Guidelines for the management of abnormal pap smear. Società Italiana di Colposcopia e Patologia Cervico Vaginale. 2006;1:1–2.
    1. Massad L. S., Einstein M. H., Huh W. K., et al. 2012 updated consensus guidelines for the management of abnormal cervical cancer screening tests and cancer precursors. Obstetrics and Gynecology. 2013;121(4):829–846. doi: 10.1097/AOG.0b013e3182883a34. - DOI - PubMed
    1. Moscicki A. B., Shiboski S., Hills N. K., et al. Regression of low-grade squamous intra-epithelial lesions in young women. Lancet. 2004;364(9446):1678–1683. doi: 10.1016/S0140-6736(04)17354-6. - DOI - PubMed

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