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Review
. 2021 Mar 19:13:339-344.
doi: 10.2147/JEP.S297682. eCollection 2021.

The Pathological Role of Pro(Renin) Receptor in Renal Inflammation

Syed S Quadri  1 , Caleb Cooper  2 , Dawood Ghaffar  1 , Hitesh Vaishnav  1 , Ludmila Nahar  3
Affiliations
Review

The Pathological Role of Pro(Renin) Receptor in Renal Inflammation

Syed S Quadri et al. J Exp Pharmacol. .

Abstract

(Pro)renin receptor (PRR) is the recently discovered component of the renin-angiotensin-aldosterone system (RAS). Many organs contain their own RAS, wherein PRR can exert organ-specific localized effects. The Binding of prorenin/renin to PRR activates angiotensin-dependent and independent pathways which leads to the development of physiological and pathological effects. Continued progress in PRR research suggests that the upregulation of PRR contributes to the development of hypertension, glomerular injury, and progression of kidney disease and inflammation. In the current review, we highlight the function of the PRR in renal inflammation in pathophysiological conditions.

Keywords: diabetes; hypertension; prorenin receptor; renal inflammation; renin-angiotensin system.

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Conflict of interest statement

The authors report no conflicts of interest in this work.

Figures

Figure 1
Figure 1
(A) Biology and signaling of (pro)renin receptor. Representative schematic organization. (B) (Pro)renin receptor (PRR) signaling pathways. Activation/upregulation of PRR induces kidney damage via ERK1/2, MAPK, NF-ҡB, TNF-α pathway.
See this image and copyright information in PMC

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