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. 1988 Jan-Feb;83(1):32-42.
doi: 10.1007/BF01907102.

Chemomechanics of altered perfusion pressure in rat hearts

T A Watters  1 , E Botvinick, W W Parmley, S Wu, J Wikman-Coffelt
Affiliations

Chemomechanics of altered perfusion pressure in rat hearts

T A Watters et al. Basic Res Cardiol. 1988 Jan-Feb.

Abstract

In an apex-ejecting isolated perfused working rat heart, as well as isovolumic preparations of rat hearts, perfusion pressure was studied independent of afterload. A decrease in perfusion pressure caused an immediate decrease in developed pressure (10s). There was a significant increase in free Pi and the phosphorylation potential after 20-30 min of perfusion at a reduced coronary flow induced by a reduction in perfusion pressure. Developed pressure decreased prior to the phosphorylation potential and inorganic phosphate; however, the phosphorylation set a limit to maximum work performance. At a perfusion pressure of 140 cm H2O and an afterload of 140 cm H2O, work imposed on the heart was maximum; there was no further increase in work.

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