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Review
. 2021 Mar 10:11:553706.
doi: 10.3389/fonc.2021.553706. eCollection 2021.

CircRNA-Mediated Regulation of Angiogenesis: A New Chapter in Cancer Biology

Shaotao Jiang  1 , Rongdang Fu  2 , Jiewei Shi  3 , Huijie Wu  4 , Jialuo Mai  1 , Xuefeng Hua  1 , Huan Chen  1 , Jie Liu  1 , Minqiang Lu  1 , Ning Li  1
Affiliations
Review

CircRNA-Mediated Regulation of Angiogenesis: A New Chapter in Cancer Biology

Shaotao Jiang et al. Front Oncol. .

Abstract

Angiogenesis is necessary for carcinoma progression and is regulated by a variety of pro- and anti-angiogenesis factors. CircRNAs are RNA molecules that do not have a 5'-cap or a 3'-polyA tail and are involved in a variety of biological functions. While circRNA-mediated regulation of tumor angiogenesis has received much attention, the detailed biological regulatory mechanism remains unclear. In this review, we investigated circRNAs in tumor angiogenesis from multiple perspectives, including its upstream and downstream factors. We believe that circRNAs have natural advantages and great potential for the diagnosis and treatment of tumors, which deserves further exploration.

Keywords: VEGF; circRNA; miRNA; signaling pathways; tumor angiogenesis.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
The role of circRNAs in pro-angiogenesis and anti-angiogenesis in bladder cancer.
Figure 2
Figure 2
CircRNAs mediate angiogenesis in pancreatic ductal adenocarcinoma, breast cancer, and hepatocellular carcinoma.
Figure 3
Figure 3
The role of circRNAs in pro-angiogenesis and anti-angiogenesis in glioblastoma.
See this image and copyright information in PMC

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