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. 1988 May 31;153(1):435-40.
doi: 10.1016/s0006-291x(88)81243-9.

Amino acid sequence of porcine heart fumarase

J C Sacchettini  1 , M W Frazier, D C Chiara, L J Banaszak, G A Grant
Affiliations

Amino acid sequence of porcine heart fumarase

J C Sacchettini et al. Biochem Biophys Res Commun. .

Abstract

The complete amino acid sequence of porcine heart fumarase (EC 4.2.1.2) has been determined from peptides produced by cyanogen bromide, endoproteinase Arg-C, S. aureus V8 protease, and trypsin. The enzyme is a tetramer of identical subunits with Mr = 50,015 and composed of 466 amino acid residues. Porcine heart fumarase displays 96% identity to human liver fumarase. Prediction of the secondary structural elements of porcine fumarase indicate that the enzyme contains a large amount of alpha helix with very little beta structure.

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