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. 2021 Mar 10:8:630090.
doi: 10.3389/fcvm.2021.630090. eCollection 2021.

Clinical Safety and Efficacy of Ablation for Atrial Fibrillation Patients With a History of Stroke

Zi-Liang Song  1 , Shao-Hui Wu  1 , Dao-Liang Zhang  1 , Wei-Feng Jiang  1 , Mu Qin  1 , Xu Liu  1
Affiliations

Clinical Safety and Efficacy of Ablation for Atrial Fibrillation Patients With a History of Stroke

Zi-Liang Song et al. Front Cardiovasc Med. .

Abstract

Objectives: To evaluate the clinical safety and efficacy of radiofrequency catheter ablation for atrial fibrillation patients with a history of stroke. Methods and Results: A total of 116 symptomatic, drug-refractory AF patients with a history of stroke, and 1:2 matched patients without a history of stroke were enrolled. Of these, 28 cases occurred stroke within 3 months (Group 1), 88 cases with stroke history longer than 3 months (Group 2), and 232 cases without stroke (Group 3). PVI was performed in all patients, extended to ablation of linear lesions ablation. The periprocedural stroke rates and other procedure-related in-hospital complications did not differ significantly among the three groups. The maintenance rate of SR after the procedure showed no significant difference (p = 0.333), 52.7, 66.4, and 70.7% in Group 1, 2, and 3, respectively. Furthermore, the comparison between a history of stroke and those without it were also shown no significant difference (p = 0.351). Conclusions: Radiofrequency ablation for AF patients occurred stroke, even within 3 months is safe and effective, without higher periprocedural complication rate and recurrence rate.

Keywords: atrial fibrillation; catheter ablation; efficacy; safety; stroke.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Long-term clinical outcomes. (A) The Kaplan–Meier plot of AF/AT-free survival for patients among the three groups. (B) The Kaplan–Meier plot of AF/AT-free survival for patients between the patients with a history of stroke (group 1 and 2) and those without it (group 3).
See this image and copyright information in PMC

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References

    1. Sherman DG, Kim SG, Boop BS, Corley SD, Dimarco JP, Hart RG, et al. . Occurrence and characteristics of stroke events in the Atrial Fibrillation Follow-up Investigation of Sinus Rhythm Management (AFFIRM) study. Arch Intern Med. (2005) 165:1185–91. 10.1001/archinte.165.10.1185 - DOI - PubMed
    1. Mozaffarian D, Benjamin EJ, Go AS, Arnett DK, Blaha MJ, Cushman M, et al. . Heart disease and stroke statistics−2015 update: a report from the American Heart Association. Circulation. (2015) 131:e29–322. 10.1161/CIR.0000000000000152 - DOI - PubMed
    1. Hayden DT, Hannon N, Callaly E, Ní Chróinín D, Horgan G, Kyne L, et al. . Rates and determinants of 5-year outcomes after atrial fibrillation-related stroke: a population study. Stroke. (2015) 46:3488–93. 10.1161/STROKEAHA.115.011139 - DOI - PubMed
    1. González Toledo ME, Klein FR, Riccio PM, Cassará FP, Muñoz Giacomelli F, Racosta JM, et al. . Atrial fibrillation detected after acute ischemic stroke: evidence supporting the neurogenic hypothesis. J Stroke Cerebrovasc Dis. (2013) 22:e486–91. 10.1016/j.jstrokecerebrovasdis.2013.05.015 - DOI - PubMed
    1. Kirchhof P, Camm AJ, Goette A, Brandes A, Eckardt L, Elvan A, et al. . Early rhythm-control therapy in patients with atrial fibrillation. N Engl J Med. (2020) 383:1305–16. 10.1056/NEJMoa2019422 - DOI - PubMed