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Case Reports
. 2021 Mar 23;5(4):e552.
doi: 10.1097/HS9.0000000000000552. eCollection 2021 Apr.

Hereditary Predisposition to Acute Myeloid Leukemia in Older Adults

Laurène Fenwarth  1   2 , Alexis Caulier  3   4 , Emma Lachaier  5 , Laure Goursaud  1   2 , Alice Marceau-Renaut  1   2 , Elise Fournier  1   2 , Delphine Lebon  3   4 , Thomas Boyer  3   4 , Céline Berthon  1   2 , Jean-Pierre Marolleau  3   4 , Claude Preudhomme  1   2 , Nicolas Duployez  1   2
Affiliations
Case Reports

Hereditary Predisposition to Acute Myeloid Leukemia in Older Adults

Laurène Fenwarth et al. Hemasphere. .
No abstract available

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Figures

Figure 1.
Figure 1.
Patients’ characteristics. The left panel depicts the pedigrees harboring germline mutations in RUNX1 (A), TET2 (B), and DDX41 (C). Age at diagnosis of AML (red color) or other hematological malignancy (blue color) is indicated inside the symbols. The reported patient in each family is indicated with an arrow. The right panel (fish diagrams D–F) shows putative clonal hierarchies at diagnosis of AML in the patients. The symbols indicate individuals carrying the germline mutation (“+”) or not (“–“) or whose the status is unknown (“?”). AML = acute myeloid leukemia; CH = clonal hematopoiesis; VAF = variant allele frequency.
Figure 2.
Figure 2.
Age of onset of hematological malignancies in germline mutation carriers. The plots show the predominant age of acute leukemia/myelodysplastic syndrome onset. The median age at diagnosis is indicated for each gene.
See this image and copyright information in PMC

References

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