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. 2021 Jul;41(8):949-956.
doi: 10.1002/pd.5940. Epub 2021 Apr 5.

Fetoscopic myelomeningocoele closure: Is the scientific evidence enough to challenge the gold standard for prenatal surgery?

E Joanne Verweij  1   2 , Martine C de Vries  3 , Esther J Oldekamp  3 , Alex J Eggink  1 , Dick Oepkes  2 , Femke Slaghekke  2 , Jochem K H Spoor  4 , Jan A Deprest  5   6 , Jena L Miller  7 , Ahmet A Baschat  7 , Philip L J DeKoninck  1
Affiliations

Fetoscopic myelomeningocoele closure: Is the scientific evidence enough to challenge the gold standard for prenatal surgery?

E Joanne Verweij et al. Prenat Diagn. 2021 Jul.

Abstract

Since the completion of the Management of Myelomeningocoele Study, maternal-fetal surgery for spina bifida has become a valid option for expecting parents. More recently, multiple groups are exploring a minimally invasive approach and recent outcomes have addressed many of the initial concerns with this approach. Based on a previously published framework, we attempt to delineate the developmental stage of the surgical techniques. Furthermore, we discuss the barriers of performing randomized controlled trials comparing two surgical interventions and suggest that data collection through registries is an alternative method to gather high-grade evidence.

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Conflict of interest statement

No conflicts of interests to disclose.

Figures

FIGURE 1
FIGURE 1
Adapted from Provoost et al. Assessment tool for the transition from an experimental treatment to an innovative treatment and to an established treatment
See this image and copyright information in PMC

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