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. 2021 May 1;320(5):E976-E988.
doi: 10.1152/ajpendo.00156.2020. Epub 2021 Mar 29.

In vitro chronic glycation induces AGEs accumulation reducing insulin-stimulated glucose uptake and increasing GLP1R in adipocytes

Nino-Cristiano Chilelli  1 , Alessia Faggian  2 , Francesca Favaretto  2 , Gabriella Milan  2 , Chiara Compagnin  2 , Francesca Dassie  2 , Silvia Bettini  2 , Marco Roverso  3 , Roberta Seraglia  4 , Annunziata Lapolla  1 , Roberto Vettor  2
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Free article

In vitro chronic glycation induces AGEs accumulation reducing insulin-stimulated glucose uptake and increasing GLP1R in adipocytes

Nino-Cristiano Chilelli et al. Am J Physiol Endocrinol Metab. .
Free article

Abstract

Intracellular AGEs accumulation increases RAGE and GLP1R and reduces glucose uptake in adipocytes.

Keywords: 3T3-L1 and human adipocytes; GLP1R; GLUT4; advanced glycation end products (AGEs); diabetes.

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