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. 2021 May 1;78(5):617-619.
doi: 10.1001/jamaneurol.2021.0477.

Residual Fatigue and Cognitive Deficits in Patients After Leucine-Rich Glioma-Inactivated 1 Antibody Encephalitis

Sophie N M Binks  1   2 , Michele Veldsman  3 , Ava Easton  4   5 , M Isabel Leite  1   2 , David Okai  6 , Masud Husain  3   7 , Sarosh R Irani  1   2
Affiliations

Residual Fatigue and Cognitive Deficits in Patients After Leucine-Rich Glioma-Inactivated 1 Antibody Encephalitis

Sophie N M Binks et al. JAMA Neurol. .

Abstract

This study evaluates residual fatigue and cognitive defects in patients after leucine-rich glioma-inactivated 1 antibody encephalitis.

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Conflict of interest statement

Conflict of Interest Disclosures: Dr Binks reported grants from Wellcome Trust and grants from the National Institute for Health Research during the conduct of the study; in addition, Dr Binks had a patent for PCT/GB2019/051257 pending University of Oxford. Dr Husain reported personal fees from Otsuka Consulting, Biogen, Excemed, and Lilly outside the submitted work. Dr Irani reported grants and personal fees from UCB Pharma and grants from CSL outside the submitted work; in addition, Dr Irani had a patent for LGI1/Caspr2 antibody detection with royalties paid from euroImmun AG and a patent for antibody diagnostics issued. No other disclosures were reported.

Figures

Figure.
Figure.. Outcomes in Patients With Leucine-Rich Glioma-Inactivated 1 Antibody Encephalitis
A. Peak illness to postillness scores in physician-rated modified Rankin Scale (mRS) and Clinical Assessment Scale in Autoimmune Encephalitis (CASE). B. Results of patient outcome assessments across multiple domains. Bar graph depicting proportion of patients with abnormal scores. Shading denotes neuropsychiatric scores from Hospital Anxiety and Depression Scale (borderline abnormal or abnormal) (CASE not depicted because no normative value for healthy controls exists). Fatigue scales were introduced during the study and completed by 31 patients: those without or with fatigue questionnaires were closely matched other than a shorter duration from illness onset in the latter group (37.7 vs 75.4 months; t(51.74) = 3.270; P = .002). C. Single-correlation R values and Pearson correlation shown across outcome measures (Bonferroni-adjusted for multiple comparisons, with outlined boxes for P <.01). D. Graphs show correlations between fatigue z score (x-axes) and mRS, Addenbrooke’s Cognitive Examination (ACE), and depression/anxiety (both derived from Hospital Anxiety and Depression Scale). FAB indicates Frontal Assessment Battery; FSMC, Fatigue Scale for Motor and Cognitive Function; MFIS, Modified Fatigue Impact Scale; MMSE, Mini-Mental State Examination. aP < .01. bP < .001.
See this image and copyright information in PMC

References

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