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. 1988 Apr;68(4):401-3.
doi: 10.1111/j.1365-2141.1988.tb04225.x.

Alkaline phosphatase positive precursors of adipocytes in the human bone marrow

P Bianco  1 , M Costantini, L C Dearden, E Bonucci
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Alkaline phosphatase positive precursors of adipocytes in the human bone marrow

P Bianco et al. Br J Haematol. 1988 Apr.

Abstract

Developing fat cells in the bone marrow of leukaemic patients treated with chemotherapy were found to be endowed with membrane-bound alkaline phosphatase. Since alkaline phosphatase is a cytochemical marker of 'reticular' cells, this observation provides cytochemical evidence that reticular cells may convert to adipocytes when marrow cellularity abruptly decreases.

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