Pathogenesis Mediated by Bacterial Membrane Vesicles

doi:10.1007/978-3-030-67171-6_6

. 2021:97:101-150.

doi: 10.1007/978-3-030-67171-6_6.

Pathogenesis Mediated by Bacterial Membrane Vesicles

William J Gilmore^{1

2}, Natalie J Bitto^{1

2}, Maria Kaparakis-Liaskos^{3

4}

Affiliations

¹ Department of Physiology, Anatomy and Microbiology, La Trobe University, Melbourne, VIC, Australia.
² Research Centre for Extracellular Vesicles, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC, Australia.
³ Department of Physiology, Anatomy and Microbiology, La Trobe University, Melbourne, VIC, Australia. m.liaskos@latrobe.edu.au.
⁴ Research Centre for Extracellular Vesicles, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC, Australia. m.liaskos@latrobe.edu.au.

PMID: 33779916
DOI: 10.1007/978-3-030-67171-6_6

Pathogenesis Mediated by Bacterial Membrane Vesicles

William J Gilmore et al. Subcell Biochem. 2021.

. 2021:97:101-150.

doi: 10.1007/978-3-030-67171-6_6.

Authors

William J Gilmore^{1

2}, Natalie J Bitto^{1

2}, Maria Kaparakis-Liaskos^{3

4}

Affiliations

¹ Department of Physiology, Anatomy and Microbiology, La Trobe University, Melbourne, VIC, Australia.
² Research Centre for Extracellular Vesicles, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC, Australia.
³ Department of Physiology, Anatomy and Microbiology, La Trobe University, Melbourne, VIC, Australia. m.liaskos@latrobe.edu.au.
⁴ Research Centre for Extracellular Vesicles, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC, Australia. m.liaskos@latrobe.edu.au.

PMID: 33779916
DOI: 10.1007/978-3-030-67171-6_6

Abstract

The release of extracellular vesicles (EVs) is a process conserved across the three domains of life. Amongst prokaryotes, EVs produced by Gram-negative bacteria, termed outer membrane vesicles (OMVs), were identified more than 50 years ago and a wealth of literature exists regarding their biogenesis, composition and functions. OMVs have been implicated in benefiting numerous metabolic functions of their parent bacterium. Additionally, OMVs produced by pathogenic bacteria have been reported to contribute to pathology within the disease setting. By contrast, the release of EVs from Gram-positive bacteria, known as membrane vesicles (MVs), has only been widely accepted within the last decade. As such, there is a significant disproportion in knowledge regarding MVs compared to OMVs. Here we provide an overview of the literature regarding bacterial membrane vesicles (BMVs) produced by pathogenic and commensal bacteria. We highlight the mechanisms of BMV biogenesis and their roles in assisting bacterial survival, in addition to discussing their functions in promoting disease pathologies and their potential use as novel therapeutic strategies.

Keywords: Bacterial membrane vesicles (BMVs); Bacterial pathogenesis; Membrane vesicles (MVs); Outer membrane vesicles (OMVs); Therapeutic applications of BMVs.

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References

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[1] Acheson DW, Luccioli S (2004) Microbial-gut interactions in health and disease. Mucosal immune responses. Best Pract Res Clin Gastroenterol 18(2):387–404 - DOI

[2] Acheson DW, Luccioli S (2004) Microbial-gut interactions in health and disease. Mucosal immune responses. Best Pract Res Clin Gastroenterol 18(2):387–404 - DOI

[3] Ahmadi Badi S, Moshiri A, Fateh A, Rahimi Jamnani F, Sarshar M, Vaziri F, Siadat SD (2017) Microbiota-Derived Extracellular Vesicles as New Systemic Regulators. Front Microbiol 8:1610. https://doi.org/10.3389/fmicb.2017.01610 - DOI - PubMed - PMC

[4] Ahmadi Badi S, Moshiri A, Fateh A, Rahimi Jamnani F, Sarshar M, Vaziri F, Siadat SD (2017) Microbiota-Derived Extracellular Vesicles as New Systemic Regulators. Front Microbiol 8:1610. https://doi.org/10.3389/fmicb.2017.01610 - DOI - PubMed - PMC

[5] Akira S, Uematsu S, Takeuchi O (2006) Pathogen recognition and innate immunity. Cell 124(4):783–801. https://doi.org/10.1016/j.cell.2006.02.015 - DOI - PubMed

[6] Akira S, Uematsu S, Takeuchi O (2006) Pathogen recognition and innate immunity. Cell 124(4):783–801. https://doi.org/10.1016/j.cell.2006.02.015 - DOI - PubMed

[7] Alaniz RC, Deatherage BL, Lara JC, Cookson BT (2007) Membrane vesicles are immunogenic facsimiles of Salmonella typhimurium that potently activate dendritic cells, prime B and T cell responses, and stimulate protective immunity in vivo. Journal of immunology (Baltimore, Md: 1950) 179. doi: https://doi.org/10.4049/jimmunol.179.11.7692

[8] Alaniz RC, Deatherage BL, Lara JC, Cookson BT (2007) Membrane vesicles are immunogenic facsimiles of Salmonella typhimurium that potently activate dendritic cells, prime B and T cell responses, and stimulate protective immunity in vivo. Journal of immunology (Baltimore, Md: 1950) 179. doi: https://doi.org/10.4049/jimmunol.179.11.7692

[9] Altindis E, Fu Y, Mekalanos JJ (2014) Proteomic analysis of Vibrio cholerae outer membrane vesicles. Proc Natl Acad Sci 111(15):E1548–E1556. https://doi.org/10.1073/pnas.1403683111 - DOI - PubMed

[10] Altindis E, Fu Y, Mekalanos JJ (2014) Proteomic analysis of Vibrio cholerae outer membrane vesicles. Proc Natl Acad Sci 111(15):E1548–E1556. https://doi.org/10.1073/pnas.1403683111 - DOI - PubMed

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Pathogenesis Mediated by Bacterial Membrane Vesicles

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