Extracellular Vesicles in Chemoresistance

doi:10.1007/978-3-030-67171-6_9

. 2021:97:211-245.

doi: 10.1007/978-3-030-67171-6_9.

Extracellular Vesicles in Chemoresistance

Gabriele De Rubis¹, Mary Bebawy²

Affiliations

¹ Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Sydney, Australia.
² Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Sydney, Australia. mary.bebawy@uts.edu.au.

PMID: 33779919
DOI: 10.1007/978-3-030-67171-6_9

Extracellular Vesicles in Chemoresistance

Gabriele De Rubis et al. Subcell Biochem. 2021.

. 2021:97:211-245.

doi: 10.1007/978-3-030-67171-6_9.

Authors

Gabriele De Rubis¹, Mary Bebawy²

Affiliations

¹ Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Sydney, Australia.
² Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Sydney, Australia. mary.bebawy@uts.edu.au.

PMID: 33779919
DOI: 10.1007/978-3-030-67171-6_9

Abstract

Chemotherapy represents the current mainstay therapeutic approach for most types of cancer. Despite the development of targeted chemotherapeutic strategies, the efficacy of anti-cancer drugs is severely limited by the development of drug resistance. Multidrug resistance (MDR) consists of the simultaneous resistance to various unrelated cytotoxic drugs and is one of the main causes of anticancer treatment failure. One of the principal mechanisms by which cancer cells become MDR involves the overexpression of ATP Binding Cassette (ABC) transporters, such as P-glycoprotein (P-gp), mediating the active efflux of cytotoxic molecules from the cytoplasm. Extracellular vesicles (EVs) are submicron lipid-enclosed vesicles that are released by all cells and which play a fundamental role in intercellular communication in physiological and pathological contexts. EVs have fundamental function at each step of cancer development and progression. They mediate the transmission of MDR through the transfer of vesicle cargo including functional ABC transporters as well as nucleic acids, proteins and lipids. Furthermore, EVs mediate MDR by sequestering anticancer drugs and stimulate cancer cell migration and invasion. EVs also mediate the communication with the tumour microenvironment and the immune system, resulting in increased angiogenesis, metastasis and immune evasion. All these actions contribute directly and indirectly to the development of chemoresistance and treatment failure. In this chapter, we describe the many roles EVs play in the acquisition and spread of chemoresistance in cancer. We also discuss possible uses of EVs as pharmacological targets to overcome EV-mediated drug resistance and the potential that the analysis of tumour-derived EVs offers as chemoresistance biomarkers.

Keywords: Biomarkers; Cancer; Chemotherapy; Extracellular vesicles; Immune evasion; Intercellular communication; Metastasis; Microparticles; Multidrug resistance; P-glycoprotein; miRNA.

PubMed Disclaimer

Cited by

Applications and advancements of nanoparticle-based drug delivery in alleviating lung cancer and chronic obstructive pulmonary disease.
De Rubis G, Paudel KR, Corrie L, Mehndiratta S, Patel VK, Kumbhar PS, Manjappa AS, Disouza J, Patravale V, Gupta G, Manandhar B, Rajput R, Robinson AK, Reyes RJ, Chakraborty A, Chellappan DK, Singh SK, Oliver BGG, Hansbro PM, Dua K. De Rubis G, et al. Naunyn Schmiedebergs Arch Pharmacol. 2024 May;397(5):2793-2833. doi: 10.1007/s00210-023-02830-w. Epub 2023 Nov 22. Naunyn Schmiedebergs Arch Pharmacol. 2024. PMID: 37991539 Review.
Recent trends and therapeutic potential of phytoceutical-based nanoparticle delivery systems in mitigating non-small cell lung cancer.
Haysom-McDowell A, Paudel KR, Yeung S, Kokkinis S, El Sherkawi T, Chellappan DK, Adams J, Dua K, De Rubis G. Haysom-McDowell A, et al. Mol Oncol. 2025 Jan;19(1):15-36. doi: 10.1002/1878-0261.13764. Epub 2024 Nov 26. Mol Oncol. 2025. PMID: 39592417 Free PMC article. Review.
A Current Synopsis of the Emerging Role of Extracellular Vesicles and Micro-RNAs in Pancreatic Cancer: A Forward-Looking Plan for Diagnosis and Treatment.
Trifylli EM, Kriebardis AG, Koustas E, Papadopoulos N, Fortis SP, Tzounakas VL, Anastasiadi AT, Sarantis P, Vasileiadi S, Tsagarakis A, Aloizos G, Manolakopoulos S, Deutsch M. Trifylli EM, et al. Int J Mol Sci. 2024 Mar 17;25(6):3406. doi: 10.3390/ijms25063406. Int J Mol Sci. 2024. PMID: 38542378 Free PMC article. Review.
Liposomal encapsulated curcumin attenuates lung cancer proliferation, migration, and induces apoptosis.
Kokkinis S, Paudel KR, De Rubis G, Yeung S, Singh M, Singh SK, Gupta G, Panth N, Oliver B, Dua K. Kokkinis S, et al. Heliyon. 2024 Sep 25;10(19):e38409. doi: 10.1016/j.heliyon.2024.e38409. eCollection 2024 Oct 15. Heliyon. 2024. PMID: 39416833 Free PMC article.
Progress in the studies on the molecular mechanisms associated with multidrug resistance in cancers.
Zhang L, Ye B, Chen Z, Chen ZS. Zhang L, et al. Acta Pharm Sin B. 2023 Mar;13(3):982-997. doi: 10.1016/j.apsb.2022.10.002. Epub 2022 Oct 7. Acta Pharm Sin B. 2023. PMID: 36970215 Free PMC article. Review.

References

1. Akao Y, Khoo F, Kumazaki M, Shinohara H, Miki K, Yamada N (2014) Extracellular disposal of tumor-suppressor miRs-145 and -34a via microvesicles and 5-FU resistance of human colon cancer cells. Int J Mol Sci 15(1):1392–1401. https://doi.org/10.3390/ijms15011392 - DOI - PubMed - PMC
1. Asare-Werehene M, Nakka K, Reunov A, Chiu CT, Lee WT, Abedini MR, Wang PW, Shieh DB, Dilworth FJ, Carmona E, Le T, Mes-Masson AM, Burger D, Tsang BK (2020) The exosome-mediated autocrine and paracrine actions of plasma gelsolin in ovarian cancer chemoresistance. Oncogene 39(7):1600–1616. https://doi.org/10.1038/s41388-019-1087-9 - DOI - PubMed
1. Aung T, Chapuy B, Vogel D, Wenzel D, Oppermann M, Lahmann M, Weinhage T, Menck K, Hupfeld T, Koch R, Trümper L, Wulf GG (2011) Exosomal evasion of humoral immunotherapy in aggressive B-cell lymphoma modulated by ATP-binding cassette transporter A3. Proc Natl Acad Sci U S A 108(37):15336–15341. https://doi.org/10.1073/pnas.1102855108 - DOI - PubMed - PMC
1. Bart J, Groen HJ, Hendrikse NH, van der Graaf WT, Vaalburg W, de Vries EG (2000) The blood-brain barrier and oncology: new insights into function and modulation. Cancer Treat Rev 26(6):449–462. https://doi.org/10.1053/ctrv.2000.0194 - DOI - PubMed
1. Battke C, Ruiss R, Welsch U, Wimberger P, Lang S, Jochum S, Zeidler R (2011) Tumour exosomes inhibit binding of tumour-reactive antibodies to tumour cells and reduce ADCC. Cancer Immunol Immunother 60(5):639–648. https://doi.org/10.1007/s00262-011-0979-5 - DOI - PubMed

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions

LinkOut - more resources

Full Text Sources
- Springer
Other Literature Sources
- scite Smart Citations
Medical
- MedlinePlus Health Information
Miscellaneous
- NCI CPTAC Assay Portal

[1] Akao Y, Khoo F, Kumazaki M, Shinohara H, Miki K, Yamada N (2014) Extracellular disposal of tumor-suppressor miRs-145 and -34a via microvesicles and 5-FU resistance of human colon cancer cells. Int J Mol Sci 15(1):1392–1401. https://doi.org/10.3390/ijms15011392 - DOI - PubMed - PMC

[2] Akao Y, Khoo F, Kumazaki M, Shinohara H, Miki K, Yamada N (2014) Extracellular disposal of tumor-suppressor miRs-145 and -34a via microvesicles and 5-FU resistance of human colon cancer cells. Int J Mol Sci 15(1):1392–1401. https://doi.org/10.3390/ijms15011392 - DOI - PubMed - PMC

[3] Asare-Werehene M, Nakka K, Reunov A, Chiu CT, Lee WT, Abedini MR, Wang PW, Shieh DB, Dilworth FJ, Carmona E, Le T, Mes-Masson AM, Burger D, Tsang BK (2020) The exosome-mediated autocrine and paracrine actions of plasma gelsolin in ovarian cancer chemoresistance. Oncogene 39(7):1600–1616. https://doi.org/10.1038/s41388-019-1087-9 - DOI - PubMed

[4] Asare-Werehene M, Nakka K, Reunov A, Chiu CT, Lee WT, Abedini MR, Wang PW, Shieh DB, Dilworth FJ, Carmona E, Le T, Mes-Masson AM, Burger D, Tsang BK (2020) The exosome-mediated autocrine and paracrine actions of plasma gelsolin in ovarian cancer chemoresistance. Oncogene 39(7):1600–1616. https://doi.org/10.1038/s41388-019-1087-9 - DOI - PubMed

[5] Aung T, Chapuy B, Vogel D, Wenzel D, Oppermann M, Lahmann M, Weinhage T, Menck K, Hupfeld T, Koch R, Trümper L, Wulf GG (2011) Exosomal evasion of humoral immunotherapy in aggressive B-cell lymphoma modulated by ATP-binding cassette transporter A3. Proc Natl Acad Sci U S A 108(37):15336–15341. https://doi.org/10.1073/pnas.1102855108 - DOI - PubMed - PMC

[6] Aung T, Chapuy B, Vogel D, Wenzel D, Oppermann M, Lahmann M, Weinhage T, Menck K, Hupfeld T, Koch R, Trümper L, Wulf GG (2011) Exosomal evasion of humoral immunotherapy in aggressive B-cell lymphoma modulated by ATP-binding cassette transporter A3. Proc Natl Acad Sci U S A 108(37):15336–15341. https://doi.org/10.1073/pnas.1102855108 - DOI - PubMed - PMC

[7] Bart J, Groen HJ, Hendrikse NH, van der Graaf WT, Vaalburg W, de Vries EG (2000) The blood-brain barrier and oncology: new insights into function and modulation. Cancer Treat Rev 26(6):449–462. https://doi.org/10.1053/ctrv.2000.0194 - DOI - PubMed

[8] Bart J, Groen HJ, Hendrikse NH, van der Graaf WT, Vaalburg W, de Vries EG (2000) The blood-brain barrier and oncology: new insights into function and modulation. Cancer Treat Rev 26(6):449–462. https://doi.org/10.1053/ctrv.2000.0194 - DOI - PubMed

[9] Battke C, Ruiss R, Welsch U, Wimberger P, Lang S, Jochum S, Zeidler R (2011) Tumour exosomes inhibit binding of tumour-reactive antibodies to tumour cells and reduce ADCC. Cancer Immunol Immunother 60(5):639–648. https://doi.org/10.1007/s00262-011-0979-5 - DOI - PubMed

[10] Battke C, Ruiss R, Welsch U, Wimberger P, Lang S, Jochum S, Zeidler R (2011) Tumour exosomes inhibit binding of tumour-reactive antibodies to tumour cells and reduce ADCC. Cancer Immunol Immunother 60(5):639–648. https://doi.org/10.1007/s00262-011-0979-5 - DOI - PubMed

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Extracellular Vesicles in Chemoresistance

Affiliations

Extracellular Vesicles in Chemoresistance

Authors

Affiliations

Abstract

Similar articles

Cited by

References

MeSH terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Miscellaneous