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Review
. 2021:97:483-500.
doi: 10.1007/978-3-030-67171-6_19.

The Role of Extracellular Vesicles in Sperm Function and Male Fertility

Natalie J Foot  1 , Sharad Kumar  2
Affiliations
Review

The Role of Extracellular Vesicles in Sperm Function and Male Fertility

Natalie J Foot et al. Subcell Biochem. 2021.

Abstract

Within the reproductive tract, distinct cell types must have precisely controlled communication for complex processes such as gamete production, fertilisation and implantation. Intercellular communication in many physiological processes involves extracellular vesicles (EVs). In reproductive systems, EVs have been implicated in many aspects, from gamete maturation to embryo development. Sperm develop within the testis and then exit into the epididymis in an immature form, lacking motility and fertilising capabilities. Due to their small size, compact nature of the nucleus and the lack of specific organelles, sperm are unable to perform de novo protein synthesis, and thus rely on extrinsic signals delivered from the external milieu to gain full function. Mounting evidence points to EVs as being a major provider of these signals, not just within the male reproductive tract but also within the female as the sperm make their way through a seemingly hostile environment to the oocyte. In this chapter, we review the current knowledge on EVs as mediators of sperm maturation and function and highlight their potential roles in male fertility.

Keywords: Epididymosome; Extracellular vesicle; Male fertility; Oviductosome; Prostasome; Sperm maturation; Uterosome.

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References

    1. Aalberts M, Sostaric E, Wubbolts R, Wauben MW, Nolte-'t Hoen EN, Gadella BM, Stout TA, Stoorvogel W (2013) Spermatozoa recruit prostasomes in response to capacitation induction. Biochim Biophys Acta 1834(11):2326–2335. https://doi.org/10.1016/j.bbapap.2012.08.008 - DOI - PubMed
    1. Abu-Halima M, Ludwig N, Hart M, Leidinger P, Backes C, Keller A, Hammadeh M, Meese E (2016) Altered micro-ribonucleic acid expression profiles of extracellular microvesicles in the seminal plasma of patients with oligoasthenozoospermia. Fertil Steril 106(5):1061–1069. e1063. https://doi.org/10.1016/j.fertnstert.2016.06.030 - DOI - PubMed
    1. Alcantara-Neto AS, Schmaltz L, Caldas E, Blache MC, Mermillod P, Alminana C (2020) Porcine oviductal extracellular vesicles interact with gametes and regulate sperm motility and survival. Theriogenology 155:240–255. https://doi.org/10.1016/j.theriogenology.2020.05.043 - DOI - PubMed
    1. Al-Dossary AA, Strehler EE, Martin-Deleon PA (2013) Expression and secretion of plasma membrane Ca2+-ATPase 4a (PMCA4a) during murine estrus: association with oviductal exosomes and uptake in sperm. PLoS One 8(11):e80181. https://doi.org/10.1371/journal.pone.0080181 - DOI - PubMed - PMC
    1. Al-Dossary AA, Bathala P, Caplan JL, Martin-DeLeon PA (2015) Oviductosome-sperm membrane interaction in cargo delivery: detection of fusion and underlying molecular players using three-dimensional super-resolution structured illumination microscopy (SR-SIM). J Biol Chem 290(29):17710–17723. https://doi.org/10.1074/jbc.M114.633156 - DOI - PubMed - PMC

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