The PRISMA 2020 statement: An updated guideline for reporting systematic reviews

Matthew J Page¹, Joanne E McKenzie¹, Patrick M Bossuyt², Isabelle Boutron³, Tammy C Hoffmann⁴, Cynthia D Mulrow⁵, Larissa Shamseer⁶, Jennifer M Tetzlaff⁷, Elie A Akl⁸, Sue E Brennan¹, Roger Chou⁹, Julie Glanville¹⁰, Jeremy M Grimshaw¹¹, Asbjørn Hróbjartsson¹², Manoj M Lalu¹³, Tianjing Li¹⁴, Elizabeth W Loder¹⁵, Evan Mayo-Wilson¹⁶, Steve McDonald¹, Luke A McGuinness¹⁷, Lesley A Stewart¹⁸, James Thomas¹⁹, Andrea C Tricco²⁰, Vivian A Welch²¹, Penny Whiting¹⁷, David Moher²²

Affiliations

¹ School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.
² Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Amsterdam University Medical Centres, University of Amsterdam, Amsterdam, Netherlands.
³ Université de Paris, Centre of Epidemiology and Statistics (CRESS), Inserm, Paris, France.
⁴ Institute for Evidence-Based Healthcare, Faculty of Health Sciences and Medicine, Bond University, Gold Coast, Australia.
⁵ University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America; Annals of Internal Medicine.
⁶ Knowledge Translation Program, Li Ka Shing Knowledge Institute, Toronto, Canada; School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, Ottawa, Canada.
⁷ Evidence Partners, Ottawa, Canada.
⁸ Clinical Research Institute, American University of Beirut, Beirut, Lebanon; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada.
⁹ Department of Medical Informatics and Clinical Epidemiology, Oregon Health & Science University, Portland, Oregon, United States of America.
¹⁰ York Health Economics Consortium (YHEC Ltd), University of York, York, United Kingdom.
¹¹ Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Canada; School of Epidemiology and Public Health, University of Ottawa, Ottawa, Canada; Department of Medicine, University of Ottawa, Ottawa, Canada.
¹² Centre for Evidence-Based Medicine Odense (CEBMO) and Cochrane Denmark, Department of Clinical Research, University of Southern Denmark, Odense, Denmark; Open Patient data Exploratory Network (OPEN), Odense University Hospital, Odense, Denmark.
¹³ Department of Anesthesiology and Pain Medicine, The Ottawa Hospital, Ottawa, Canada; Clinical Epidemiology Program, Blueprint Translational Research Group, Ottawa Hospital Research Institute, Ottawa, Canada; Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, Canada.
¹⁴ Department of Ophthalmology, School of Medicine, University of Colorado Denver, Denver, Colorado, United States; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America.
¹⁵ Division of Headache, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA; Head of Research, The BMJ, London, United Kingdom.
¹⁶ Department of Epidemiology and Biostatistics, Indiana University School of Public Health-Bloomington, Bloomington, Indiana, United States of America.
¹⁷ Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom.
¹⁸ Centre for Reviews and Dissemination, University of York, York, United Kingdom.
¹⁹ EPPI-Centre, UCL Social Research Institute, University College London, London, United Kingdom.
²⁰ Li Ka Shing Knowledge Institute of St. Michael's Hospital, Unity Health Toronto, Toronto, Canada; Epidemiology Division of the Dalla Lana School of Public Health and the Institute of Health Management, Policy, and Evaluation, University of Toronto, Toronto, Canada; Queen's Collaboration for Health Care Quality Joanna Briggs Institute Centre of Excellence, Queen's University, Kingston, Canada.
²¹ Methods Centre, Bruyère Research Institute, Ottawa, Ontario, Canada; School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, Ottawa, Canada.
²² Centre for Journalology, Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Canada; School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, Ottawa, Canada.

PMID: 33780438
PMCID: PMC8007028
DOI: 10.1371/journal.pmed.1003583

Guideline

The PRISMA 2020 statement: An updated guideline for reporting systematic reviews

Matthew J Page et al. PLoS Med. 2021.

. 2021 Mar 29;18(3):e1003583.

doi: 10.1371/journal.pmed.1003583. eCollection 2021 Mar.

Authors

Affiliations

¹ School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.
² Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Amsterdam University Medical Centres, University of Amsterdam, Amsterdam, Netherlands.
³ Université de Paris, Centre of Epidemiology and Statistics (CRESS), Inserm, Paris, France.
⁴ Institute for Evidence-Based Healthcare, Faculty of Health Sciences and Medicine, Bond University, Gold Coast, Australia.
⁵ University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America; Annals of Internal Medicine.
⁶ Knowledge Translation Program, Li Ka Shing Knowledge Institute, Toronto, Canada; School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, Ottawa, Canada.
⁷ Evidence Partners, Ottawa, Canada.
⁸ Clinical Research Institute, American University of Beirut, Beirut, Lebanon; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada.
⁹ Department of Medical Informatics and Clinical Epidemiology, Oregon Health & Science University, Portland, Oregon, United States of America.
¹⁰ York Health Economics Consortium (YHEC Ltd), University of York, York, United Kingdom.
¹¹ Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Canada; School of Epidemiology and Public Health, University of Ottawa, Ottawa, Canada; Department of Medicine, University of Ottawa, Ottawa, Canada.
¹² Centre for Evidence-Based Medicine Odense (CEBMO) and Cochrane Denmark, Department of Clinical Research, University of Southern Denmark, Odense, Denmark; Open Patient data Exploratory Network (OPEN), Odense University Hospital, Odense, Denmark.
¹³ Department of Anesthesiology and Pain Medicine, The Ottawa Hospital, Ottawa, Canada; Clinical Epidemiology Program, Blueprint Translational Research Group, Ottawa Hospital Research Institute, Ottawa, Canada; Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, Canada.
¹⁴ Department of Ophthalmology, School of Medicine, University of Colorado Denver, Denver, Colorado, United States; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America.
¹⁵ Division of Headache, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA; Head of Research, The BMJ, London, United Kingdom.
¹⁶ Department of Epidemiology and Biostatistics, Indiana University School of Public Health-Bloomington, Bloomington, Indiana, United States of America.
¹⁷ Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom.
¹⁸ Centre for Reviews and Dissemination, University of York, York, United Kingdom.
¹⁹ EPPI-Centre, UCL Social Research Institute, University College London, London, United Kingdom.
²⁰ Li Ka Shing Knowledge Institute of St. Michael's Hospital, Unity Health Toronto, Toronto, Canada; Epidemiology Division of the Dalla Lana School of Public Health and the Institute of Health Management, Policy, and Evaluation, University of Toronto, Toronto, Canada; Queen's Collaboration for Health Care Quality Joanna Briggs Institute Centre of Excellence, Queen's University, Kingston, Canada.
²¹ Methods Centre, Bruyère Research Institute, Ottawa, Ontario, Canada; School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, Ottawa, Canada.
²² Centre for Journalology, Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Canada; School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, Ottawa, Canada.

PMID: 33780438
PMCID: PMC8007028
DOI: 10.1371/journal.pmed.1003583

Abstract

Matthew Page and co-authors describe PRISMA 2020, an updated reporting guideline for systematic reviews and meta-analyses.

PubMed Disclaimer

Conflict of interest statement

I have read the journal’s policy and the authors of this manuscript have the following competing interests: EL is head of research for the BMJ; MJP is an editorial board member for PLOS Medicine; ACT is an associate editor and MJP, TL, EMW, and DM are editorial board members for the Journal of Clinical Epidemiology; DM and LAS were editors in chief, LS, JMT, and ACT are associate editors, and JG is an editorial board member for Systematic Reviews. None of these authors were involved in the peer review process or decision to publish. TCH has received personal fees from Elsevier outside the submitted work. EMW has received personal fees from the American Journal for Public Health, for which he is the editor for systematic reviews. VW is editor in chief of the Campbell Collaboration, which produces systematic reviews, and co-convenor of the Campbell and Cochrane equity methods group. DM is chair of the EQUATOR Network, IB is adjunct director of the French EQUATOR Centre and TCH is co-director of the Australasian EQUATOR Centre, which advocates for the use of reporting guidelines to improve the quality of reporting in research articles. JMT received salary from Evidence Partners, creator of DistillerSR software for systematic reviews; Evidence Partners was not involved in the design or outcomes of the statement, and the views expressed solely represent those of the author.

Figures

**Fig 1. PRISMA 2020 flow diagram template for systematic reviews.**
The new design is adapted from flow diagrams proposed by Boers,[55] Mayo-Wilson et al.[56] and Stovold et al.[57] The boxes in grey should only be completed if applicable; otherwise they should be removed from the flow diagram. Note that a “report” could be a journal article, preprint, conference abstract, study register entry, clinical study report, dissertation, unpublished manuscript, government report or any other document providing relevant information.

See this image and copyright information in PMC

References

1. Gurevitch J, Koricheva J, Nakagawa S, Stewart G. Meta-analysis and the science of research synthesis. Nature 2018;555:175–82. 10.1038/nature25753 - DOI - PubMed
1. Gough D, Thomas J, Oliver S. Clarifying differences between reviews within evidence ecosystems. Syst Rev 2019;8:170. 10.1186/s13643-019-1089-2 - DOI - PMC - PubMed
1. Moher D. Reporting guidelines: doing better for readers. BMC Med 2018;16:233. 10.1186/s12916-018-1226-0 - DOI - PMC - PubMed
1. Moher D, Liberati A, Tetzlaff J, Altman DG; PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Ann Intern Med 2009;151:264–9, W64. 10.7326/0003-4819-151-4-200908180-00135 - DOI - PubMed
1. Moher D, Liberati A, Tetzlaff J, Altman DG; PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. BMJ 2009;339:b2535. 10.1136/bmj.b2535 - DOI - PMC - PubMed

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The PRISMA 2020 statement: An updated guideline for reporting systematic reviews

Affiliations

The PRISMA 2020 statement: An updated guideline for reporting systematic reviews

Authors

Affiliations

Abstract

Conflict of interest statement

Figures

References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources