Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Mar 30;21(1):156.
doi: 10.1186/s12872-021-01952-4.

Association of the lymphocyte-to-monocyte ratio, mean diameter of coronary arteries, and uric acid level with coronary slow flow in isolated coronary artery ectasia

Zhuoxuan Yang  1 , Jiansong Yuan  1 , JinGang Cui  1 , Hao Guan  1 , Shubin Qiao  2
Affiliations

Association of the lymphocyte-to-monocyte ratio, mean diameter of coronary arteries, and uric acid level with coronary slow flow in isolated coronary artery ectasia

Zhuoxuan Yang et al. BMC Cardiovasc Disord. .

Abstract

Background: The pathophysiology of isolated coronary artery ectasia (CAE) with the coronary slow flow (CSF) phenomenon is still unclear. The purpose of this study was to investigate the risk factors for isolated CAE complicated with CSF.

Methods: A total of 126 patients with isolated CAE were selected retrospectively. The patients were grouped into the no CSF (NCSF) group (n = 55) and the CSF group (n = 71) according to the corrected thrombolysis in myocardial infarction (TIMI) frame count (CTFC). Data on demographics, laboratory measurements, left ventricular ejection fraction (LVEF), left ventricular end-diastolic diameter (LVEDd), CTFC and diameters of three coronary arteries were collected.

Results: The proportions of males (84.5% vs. 61.8%, p = 0.004) and patients with a smoking history (63.4% vs. 43.6%, p = 0.021) were higher in the CSF group than in the NCSF group. The neutrophil-to-lymphocyte ratio (NLR) (2.08(1.68-3.21) vs. 1.89 ± 0.58, p = 0.001), mean diameter of coronary arteries (mean D) (5.50 ± 0.85 vs. 5.18 ± 0.91, p < 0.001), and uric acid (URIC) level (370.78 ± 109.79 vs. 329.15 ± 79.71, p = 0.019) were significantly higher in the CSF group, while the lymphocyte-to-monocyte ratio (LMR) (4.81 ± 1.66 vs. 5.96 ± 1.75, p < 0.001) and albumin (ALB) level (44.13 ± 4.10 vs. 45.69 ± 4.11, p = 0.036) were lower. Multivariable logistic analysis showed that the LMR (odds ratio: 0.614, 95% CI: 0.464-0.814, p = 0.001), mean D (odds ratio: 2.643, 95% CI: 1.54-4.51, p < 0.001) and URIC level (odds ratio: 1.006, 95% CI: 1.001-1.012, p = 0.018) were independent predictors of CSF in CAE.

Conclusions: The LMR was a negative independent predictor of CSF in isolated CAE, while URIC level and mean D were positive independent predictors.

Keywords: Coronary slow flow; Isolated coronary artery ectasia; Lymphocyte-to-monocyte ratio; Mean diameter of arteries; Uric acid.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Receiver operating characteristic (ROC) curve of Mean D, LMR and URIC
See this image and copyright information in PMC

References

    1. Isik T, Ayhan E, Uyarel H, Tanboga IH, Kurt M, Uluganyan M, Ergelen M, Eksik A. Association of neutrophil to lymphocyte ratio with presence of isolated coronary artery ectasia. Turk Kardiyol Dern Ars. 2013;41(2):123–130. doi: 10.5543/tkda.2013.17003. - DOI - PubMed
    1. Ozkan B, Orscelik O, Yildirim Yaroglu H, Balci S, Ozcan MK, Celik A, Ozcan IT. Association between serum adropin levels and isolated coronary artery ectasia in patients with stable angina pectoris. Anatol J Cardiol. 2019;22(5):250–255. doi: 10.14744/AnatolJCardiol.2019.90349. - DOI - PMC - PubMed
    1. Sen N, Ozcan F, Uygur B, Aksu T, Akpinar I, Cay S, Cetin M, Sokmen E, Akcakoyun M, Maden O, Balbay Y, Erbay AR. Elevated serum uric acid levels in patients with isolated coronary artery ectasia. Turk Kardiyol Dern Ars. 2009;37(7):467–472. - PubMed
    1. Hartnell GG, Parnell BM, Pridie RB.Coronary artery ectasia. Its prevalence and clinical signifificance in 4,993 patients.Br Heart J.1985;54(4):392–395. - PMC - PubMed
    1. Hawkins BM, Stavrakis S, Rousan TA, Abu-Fadel M, Schechter E. Coronary slow flow–prevalence and clinical correlations. Circ J. 2012;76(4):936–942. doi: 10.1253/circj.cj-11-0959. - DOI - PubMed

Publication types

MeSH terms