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Comment
. 2021 Mar 29;22(1):234.
doi: 10.1186/s13063-021-05209-5.

COVID-19: underpowered randomised trials, or no randomised trials?

Atle Fretheim  1   2
Affiliations
Comment

COVID-19: underpowered randomised trials, or no randomised trials?

Atle Fretheim. Trials. .

Abstract

A recently published trial of face mask use to protect against COVID-19 demonstrated a key barrier to carrying out randomised trials in public health: the need for unattainably large sample sizes. For many public health interventions, the choice is not between sufficiently powered trials and underpowered trials, but between underpowered trials and no trials at all. Underpowered trials should be viewed as contributions to the larger body of evidence, alongside other studies of various sizes and designs, collectively assessed and synthesized in systematic reviews. Overemphasis on sample size calculation is probably more of a hindrance than a help to scientific progress.

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Conflict of interest statement

The author declares that he has no competing interests.

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References

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