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Review
. 2021 May;47(2):133-148.
doi: 10.1016/j.rdc.2021.01.001. Epub 2021 Feb 26.

Pain Mechanisms in Patients with Rheumatic Diseases

Deeba Minhas  1 , Daniel Joseph Clauw  2
Affiliations
Review

Pain Mechanisms in Patients with Rheumatic Diseases

Deeba Minhas et al. Rheum Dis Clin North Am. 2021 May.

Abstract

Patients with rheumatic diseases often have mixed pain states, with varying degrees of nociceptive, neuropathic, and nociplastic mechanisms, which exist on a continuum. When individuals with any chronic pain have a nociplastic component to their symptoms, they are less likely to respond to treatments (eg, injections, surgery, biologics, and opioids) that work better for acute or purely nociceptive pain.

Keywords: Central sensitization; Nociplastic; Pain mechanisms; Rheumatic pain.

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Conflict of interest statement

Disclosure D. Minhas has no disclosures. D.J. Clauw has performed consulting for Pfizer, Lilly, Aptinyx, Zynerba, Lundbeck, Tonix, and Samumed and has received research funds from Aptinyx and Lundbeck.

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