Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Jul;26(7):1735-1743.
doi: 10.1016/j.drudis.2021.03.017. Epub 2021 Mar 27.

Long noncoding RNAs have pivotal roles in chemoresistance of acute myeloid leukemia

Mehrdad Izadirad  1 , Leila Jafari  1 , Alva Rani James  2 , Juan Pablo Unfried  3 , Zhuo-Xun Wu  4 , Zhe-Sheng Chen  5
Affiliations
Review

Long noncoding RNAs have pivotal roles in chemoresistance of acute myeloid leukemia

Mehrdad Izadirad et al. Drug Discov Today. 2021 Jul.

Abstract

Many patients with acute myeloid leukemia (AML) experience poor outcomes following traditional high-dose chemotherapies and complete remission rates remain suboptimal. Chemoresistance is an obstacle to effective chemotherapy and the precise mechanisms involved remain to be determined. Recently, long noncoding RNAs (lncRNAs) have been identified as relevant factors in the development of drug resistance in patients with AML. Furthermore, accumulating data support the importance of lncRNAs as potentially useful novel therapeutic targets in many cancers. Here, we review the role of lncRNAs in the development and induction of the chemoresistance in AML, and suggest lncRNAs as novel molecular markers for diagnosis, prediction of patient response to chemotherapy, and novel therapeutic targets for AML.

Keywords: Acute myeloid leukemia; Chemoresistance; Long noncoding RNAs.

PubMed Disclaimer

LinkOut - more resources