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Case Reports
. 2021 Nov;479(5):1051-1053.
doi: 10.1007/s00428-021-03086-6. Epub 2021 Mar 29.

Malignant phyllodes tumour of the breast mimicking endometriosis

Andrew H S Lee  1 , Ulises Zanetto  2 , Rachna Awasthi  2 , Mei-Ju Hwang  3 , Nur Diyana Md Nasir  4 , Cedric Chuan Young Ng  5 , Bin Tean Teh  5 , Puay Hoon Tan  4   6
Affiliations
Case Reports

Malignant phyllodes tumour of the breast mimicking endometriosis

Andrew H S Lee et al. Virchows Arch. 2021 Nov.

Abstract

A 63-year-old woman presented with a clinically malignant mass. Core biopsy showed features resembling endometriosis. The glands were GATA3 and oestrogen receptor positive consistent with mammary origin and had no myoepithelial layer. The excision also showed a fibroepithelial component with stromal overgrowth, frequent mitoses and invasive margin consistent with a malignant phyllodes tumour. KMT2D and SETD2 mutations were present in both the conventional phyllodes tumour and endometriosis-like areas and are also described in endometriosis raising interesting questions about these lesions. This unusual pattern is a potential diagnostic pitfall, so it is helpful to be aware of it.

Keywords: Breast; Endometriosis; Phyllodes tumour.

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References

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