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Review
. 2021 Dec;99(8):819-825.
doi: 10.1111/aos.14816. Epub 2021 Mar 29.

Clinical applications of microperimetry in RPGR-related retinitis pigmentosa: a review

Thomas M W Buckley  1 , Jasleen K Jolly  1   2 , Amandeep Singh Josan  1   2 , Laura J Wood  1   2 , Jasmina Cehajic-Kapetanovic  1   2 , Robert E MacLaren  1   2
Affiliations
Free article
Review

Clinical applications of microperimetry in RPGR-related retinitis pigmentosa: a review

Thomas M W Buckley et al. Acta Ophthalmol. 2021 Dec.
Free article

Abstract

Microperimetry, or fundus-tracked perimetry, is a precise static-automated perimetric technique to assess central retinal function. As visual acuity only deteriorates at a late disease stage in RPGR-related retinitis pigmentosa (RP), alternative markers for disease progression are of great utility. Microperimetry assessment has been of critical value as an outcome measure in a recently reported phase I/II gene therapy trial for RPGR-related RP, both in terms of detecting safety and efficacy signals. Here, we performed a review of the literature. We describe the principles of microperimetry before outlining specific parameters that may be useful as outcome measures in clinical trial settings. The current state of structure-function correlations between short-wavelength autofluorescence, optical coherence tomography and adaptive optics in RPGR-related retinitis pigmentosa are also summarized.

Keywords: RPGR; fundus-tracked perimetry; microperimetry; retinitis pigmentosa.

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References

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