Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 May 27;29(8):1220-1232.
doi: 10.1093/eurjpc/zwab015.

Global, regional, and national burden of aortic aneurysm, 1990-2017: a systematic analysis of the Global Burden of Disease Study 2017

Stefanos Tyrovolas  1   2   3   4 , Dimitra Tyrovola  3   5 , Iago Giné-Vázquez  1   2 , Ai Koyanagi  1   2   6 , Antonio Bernabe-Ortiz  7 , Fernando Rodriguez-Artalejo  8   9 , Josep Maria Haro  1   2   10 , William K Pan  11   12 , J Jaime Miranda  7   13 , Demosthenes Panagiotakos  3
Affiliations

Global, regional, and national burden of aortic aneurysm, 1990-2017: a systematic analysis of the Global Burden of Disease Study 2017

Stefanos Tyrovolas et al. Eur J Prev Cardiol. .

Abstract

Aims: This study aimed at evaluating the age, sex, and country-income patterns in aortic aneurysm disease burden, analysing trends in mortality and years of life lost (YLLs), as well as their causal drivers and risk factors, using the 2017 Global Burden of Diseases, Injuries, and Risk Factors Study (GBD 2017).

Methods and results: We described the temporal, global, and regional (195 countries) patterns of aortic aneurysm (thoracic and abdominal) mortality, YLLs, their drivers [sociodemographic index (SDI), healthcare access and quality index (HAQ index)] and risk factors using the GBD 1990-2017. Correlation and mixed multilevel modelling between aortic aneurysm mortality, YLLs, HAQ index and other variables were applied. From 1990 to 2017, a global declining trend in age-standardized aortic aneurysm mortality was found [2.88 deaths/100 000 (95% uncertainty intervals, UI 2.79 to 3.03) in 1990 and 2.19 deaths/100 000 (95% UI 2.09 to 2.28) in 2017]. Among high-income countries (HICs) a consistent declining Spearman's correlation between age-standardised aortic aneurysm mortality, SDI (HICs; 1990 rho: 0.57, P ≤ 0.001; 2017 rho: 0.41, P = 0.001) and HAQ index was observed (HICs; 1990 rho: 0.50, P <0.001; 2016 rho: 0.35, P = 0.006); in comparison with low- and middle-income countries where correlation trends were weak and mixed. At a global level, higher HAQ index was related with lower aortic aneurysm mortality and YLLs [mortality, coef: -0.05, 95% confidence interval (CI): -0.06, -0.04; YLLs, coef: -0.94, 95% CI: -1.17, -0.71].

Conclusions: Age-standardized aortic aneurysm mortality declined globally between 1990 and 2017. Globally, age-standardized aortic aneurysm mortality and YLLs were related to changes in SDI and HAQ index levels, while country-level income-related variations were also observed.

Keywords: Aortic aneurysm; Low- and middle-income countries; Mortality; Years of life lost.

PubMed Disclaimer

Conflict of interest statement

Conflict of interest: All authors have completed the ICMJE uniform disclosure form at www.icmje.org/coi_disclosure.pdf and declare no support from any organization for the submitted work; no financial relationships with any organizations that might have an interest in the submitted work in the previous 3 years; no other relationships or activities that could appear to have influenced the submitted work. The authors report no relationships that could be construed as a conflict of interest.

Figures

Figure 1
Figure 1
Global age-standardized aortic aneurysm mortality rates for both sexes, and by males and females between 1990 and 2017.
Figure 2
Figure 2
Age-standardized aortic aneurysm mortality rates for both sexes, by GBD super-regions, between 1990 and 2017.
Figure 3
Figure 3
Age-standardized aortic aneurysm mortality rates for both sexes, by country-income levels, between 1990 and 2017. HICs, high-income countries; LICs, low-income countries; MICs, middle-income countries. Comparisons between HIC vs. LICs and MICs for the period 1990–2010 were significant (P < 0.0007).
Figure 4
Figure 4
Correlation between age-standardized aortic aneurysm mortality, sociodemographic index (A) and healthcare access and quality index (B) by country’s income level. SDI: Sociodemographic index; HAQindex: Healthcare access and quality index.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Isselbacher Eric M. Thoracic and abdominal aortic aneurysms. Circulation 2005; 111:816–828. - PubMed
    1. Eckstein H-H, Maegdefessel L. Linking obesity with abdominal aortic aneurysm-development. Eur Heart J 2020;41:2469–2471. - PMC - PubMed
    1. O’Gara PT. Aortic aneurysm. Circulation 2003;107:e43–e45. - PubMed
    1. Heikkinen M, Salenius J-P, Auvinen O. Ruptured abdominal aortic aneurysm in a well-defined geographic area. J Vasc Surg 2002;36:291–296. - PubMed
    1. GBD 2017 DALYs and HALE Collaborators. Global, regional, and national disability-adjusted life-years (DALYs) for 359 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet 2018;392: 1859–1922. - PMC - PubMed