Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Oct;28(11):6665-6672.
doi: 10.1245/s10434-021-09867-2. Epub 2021 Mar 30.

Construction and Validation of a Risk-Scoring Model that Preoperatively Predicts Lymph Node Metastasis in Early Gastric Cancer Patients

Jingtao Wei #  1 , Yinan Zhang #  1 , Yiqiang Liu #  2 , Anqiang Wang  1 , Biao Fan  1 , Tao Fu  1 , Ziyu Jia  1 , Liu He  1 , Ke Ji  1 , Xin Ji  1 , Xiaojiang Wu  1 , Ji Zhang  1 , Ziyu Li  1 , Lianhai Zhang  1 , Zhaode Bu  3 , Jiafu Ji  4
Affiliations

Construction and Validation of a Risk-Scoring Model that Preoperatively Predicts Lymph Node Metastasis in Early Gastric Cancer Patients

Jingtao Wei et al. Ann Surg Oncol. 2021 Oct.

Abstract

Objective: The aim of this study was to create a risk-scoring model to preoperatively predict the incidence of lymph node metastasis (LNM) in early gastric cancer (EGC) patients to guide treatment.

Methods: To construct the risk-scoring model, we retrospectively analyzed a primary cohort of 548 EGC patients. Univariate analysis and logistic regression were performed. A risk-scoring model for predicting LNM in EGC patients was developed based on preoperative factors, and another cohort of 73 patients was then analyzed to validate the model.

Results: In the primary cohort, LNM was pathologically confirmed in 72 (13.1%) patients. In the multivariate analysis, the presence of ulceration and tumor size on gastroscopy, undifferentiated histological type, and presence of enlarged lymph nodes on computed tomography or endoscopic ultrasonography were independent risk factors for LNM. A 17-point risk-scoring model was developed to predict LNM risk. The cut-off score of the model was 8, and the area under the receiver operating characteristic curve (AUC) of the model was 0.835 [95% confidence interval (CI) 0.784-0.886]. In the validation cohort, the AUC of the model was 0.829 (95% CI 0.699-0.959).

Conclusions: We developed and validated an effective 17-point risk-scoring model that could preoperatively predict LNM for EGC patients.

PubMed Disclaimer

References

    1. Sun D, Cao M, Li H, He S, Chen W. Cancer burden and trends in China: a review and comparison with Japan and South Korea. Chin J Cancer Res. 2020;32(2):129–39. - DOI
    1. Murakami T. Pathomorphological diagnosis: definition and gross classification of early gastric cancer. Gann Monogr Cancer Res. 1971;11:53–5.
    1. Gotoda T, Yanagisawa A, Sasako M, Ono H, Nakanishi Y, Shimoda T, et al. Incidence of lymph node metastasis from early gastric cancer: estimation with a large number of cases at two large centers. Gastric Cancer. 2000;3(4):219–25. - DOI
    1. Saka M, Katai H, Fukagawa T, Nijjar R, Sano T. Recurrence in early gastric cancer with lymph node metastasis. Gastric Cancer. 2008;11(4):214–8. - DOI
    1. Japanese Gastric Cancer Assocation. Japanese gastric cancer treatment guidelines 2018 (5th edition). Gastric Cancer. 2021;24(1):1–21.

LinkOut - more resources