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Comment
. 2021 Apr 27;118(17):e2103433118.
doi: 10.1073/pnas.2103433118.

Crossover interference: Just ZYP it

Wayne Crismani  1   2 , Chloe Girard  3 , Andrew Lloyd  4
Affiliations
Comment

Crossover interference: Just ZYP it

Wayne Crismani et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The authors declare no competing interest.

Figures

Fig. 1.
Fig. 1.
A model of interference. In wild type (wt), ZYP1 enables transmission or perception of the interference signal, preventing closely spaced crossovers. As the interference signal propagates a fixed physical distance, the longer chromosome axes in male permit more crossovers per chromosome than in female. In zyp1 mutants, homologous chromosomes coalign at a distance of ∼400 nm, compared to ∼200 nm in wt, but do not synapse due to lack of the transverse filament. In the absence of interference, 1) crossovers increase in number; 2) crossovers become randomly distributed along and among chromosomes; and 3) the difference in crossover rates between male and female meiosis is abolished.
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References

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