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. 2021 Feb 15:23:100328.
doi: 10.1016/j.ensci.2021.100328. eCollection 2021 Jun.

D-penicillamine in Wilson's disease; recognizing the transition from benefit to harm

Yihui Goh  1 , Benjamin Yong-Qiang Tan  1   2 , Nicole Ya-Yuan Chong  3 , Margaret Ma  2   4 , Manjari Lahiri  2   4 , Andrew Makmur  5 , Yee Cheun Chan  1   2 , Soon Boon Justin Wong  6 , Joy Vijayan  1   2
Affiliations

D-penicillamine in Wilson's disease; recognizing the transition from benefit to harm

Yihui Goh et al. eNeurologicalSci. .
No abstract available

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Figures

Fig. 1
Fig. 1
Magnetic resonance imaging of the brain showing subcortical T2 hyperintense lesions (arrows) at presentation (1A) and improvement 1 month post treatment (1B). The T2 basal ganglia hyperintensities present are likely secondary to Wilson's disease.
Fig. 2
Fig. 2
Skin biopsy (haematoxylin and eosin stain, magnification x 100) (A) showing features of vasculitis involving a medium-sized artery within the deep dermis - extravasation of red blood cells, karyorrhexis, neutrophils extravasation, and fibrinoid necrosis of the blood vessel wall. Miller's elastic van Gieson stain (magnification x200) (B) highlights the internal elastic lamina within the arterial wall, which is partially disrupted by the inflammation and necrosis. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)
See this image and copyright information in PMC

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References

    1. ten Holder S.M., Joy M.S., Falk R.J. Cutaneous and systemic manifestations of drug-induced vasculitis. Ann. Pharmacother. 2002;36:130–147. - PubMed
    1. Lee Y., Lee S.T. Cho H. D-penicillamine-induced ANA (+) ANCA (+) vasculitis in pediatric patients with Wilson’s disease. Clin. Nephrol. 2016;85:296–300. - PubMed
    1. Bienaimé F., Clerbaux G., Plaisier E., Mougenot B., Ronco P., Rougier J.P. D-Penicillamine-induced ANCA-associated crescentic glomerulonephritis in Wilson disease. Am. J. Kidney Dis. 2007;50:821–825. - PubMed
    1. Halla J.T., Fallahi S., Koopman W.J. Penicillamine-induced myositis. Observations and unique features in two patients and review of the literature. Am. J. Med. 1984;77:719–722. - PubMed
    1. Kimbrough R.L., Mewis L. Stewart RH. D-penicillamine and the ocular myasthenic syndrome. Ann. Ophthalmol. 1981;13:1171–1172. - PubMed

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