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. 2021 Oct;17(10):1595-1609.
doi: 10.1002/alz.12323. Epub 2021 Mar 30.

Quantifying progression in primary progressive aphasia with structural neuroimaging

Jolina Lombardi  1 , Benjamin Mayer  2 , Elisa Semler  1 , Sarah Anderl-Straub  1 , Ingo Uttner  1 , Jan Kassubek  1 , Janine Diehl-Schmid  3   4 , Adrian Danek  5 , Johannes Levin  5   6   4 , Klaus Fassbender  7 , Klaus Fliessbach  8   9 , Anja Schneider  8   9 , Hans-Jürgen Huppertz  10 , Holger Jahn  11 , Alexander Volk  12 , Johannes Kornhuber  13 , Bernhard Landwehrmeyer  1 , Martin Lauer  14 , Johannes Prudlo  15   16 , Jens Wiltfang  17 , Matthias L Schroeter  18 , Albert Ludolph  1 , Markus Otto  1 ; FTLD consortium
Affiliations

Quantifying progression in primary progressive aphasia with structural neuroimaging

Jolina Lombardi et al. Alzheimers Dement. 2021 Oct.

Abstract

Introduction: The term primary progressive aphasia (PPA) sums up the non-fluent (nfv), the semantic (sv), and the logopenic (lv) variant. Up to now, there is only limited data available concerning magnetic resonance imaging volumetry to monitor disease progression.

Methods: Structural brain imaging and an extensive assessment were applied at baseline and up to 4-year(s) follow-up in 269 participants. With automated atlas-based volumetry 56 brain regions were assessed. Atrophy progression served to calculate sample sizes for therapeutic trials.

Results: At baseline highest atrophy appeared in parts of the left frontal lobe for nfvPPA (-17%) and of the left temporal lobe for svPPA (-34%) and lvPPA (-24%). Severest progression within 1-year follow-up occurred in the basal ganglia in nfvPPA (-7%), in the hippocampus/amygdala in svPPA (-9%), and in (medial) temporal regions in lvPPA (-6%).

Conclusion: PPA presents as a left-dominant, mostly gray matter sensitive disease with considerable atrophy at baseline that proceeds variant-specific.

Keywords: atlas-based volumetry; disease progression; frontotemporal dementia; longitudinal magnetic resonance imaging; primary progressive aphasia; sample size calculation.

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References

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