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. 2021 Mar 31;8(1):34.
doi: 10.1186/s40658-021-00379-2.

Effect of quantitative values on shortened acquisition duration in brain tumor 11C-methionine PET/CT

Masatoshi Morimoto  1   2 , Nobuyuki Kudomi  3 , Yukito Maeda  4 , Takuya Kobata  4 , Akihiro Oishi  4 , Keisuke Matsumoto  4 , Toshihide Monden  4 , Takanobu Iwasaki  5 , Katsuya Mitamura  6 , Takashi Norikane  6 , Yuka Yamamoto  6 , Yoshihiro Nishiyama  6
Affiliations

Effect of quantitative values on shortened acquisition duration in brain tumor 11C-methionine PET/CT

Masatoshi Morimoto et al. EJNMMI Phys. .

Abstract

Background: The amount of signal decreases when the acquisition duration is shortened. However, it is not clear how this affects the quantitative values. This study aims to clarify the effect of acquisition time shortening in brain tumor PET/CT using 11C-methionine on the quantitative values.

Method: This study was a retrospective analysis of 30 patients who underwent clinical 11C-methionine PET/CT examination. PET images were acquired in list mode for 10 min. PET images of acquisition duration from 1 to 10 min with 1-min step were reconstructed. We examined the effect on the quantitative values of acquisition duration. We placed a volume of interest to include the entire tumor and regions of interest in the shape of a large crescent in the contralateral hemisphere in 5 contiguous axial slices as normal tissue. Quantitative values examined were maximum, peak, and mean standardized uptake values (SUVmax, SUVpeak, SUVmean), metabolic tumor volume (MTV), and maximum tumor to normal tissue ratio (TNRmax), with each duration compared to that with 10 min.

Results: SUVmax, MTV, and TNRmax showed the highest values due to the effects of statistical noise when the acquisition time was 1 min. These values were stable when the acquisition duration was > 6 min. SUVpeak and SUVmean showed mostly consistent values regardless of duration.

Conclusions: SUVmax, MTV, and TNRmax are affected by acquisition time. If the acquisition duration was > 6 min, the fluctuation could be suppressed within 5% in these quantitative values. However, SUVpeak was suggested to be a robust index regardless of the acquisition duration.

Keywords: 11C-methionine; Acquisition duration; SUVpeak; Statistical noise.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
VOI and ROI setting in clinical image
Fig. 2
Fig. 2
Change of SUVmax (a), SUVpeak (b), SUVmean (c), MTV (d), and TNRmax (e) (n = 30). Error bars indicate SD
Fig. 3
Fig. 3
The images with acquisition duration from 1 to 10 min
See this image and copyright information in PMC

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