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. 2021 Mar;170(5):654-657.
doi: 10.1007/s10517-021-05126-2. Epub 2021 Mar 31.

Expression of Genes Encoding Nuclear Factors PPARγ, LXRβ, and RORα in Epicardial and Subcutaneous Adipose Tissues in Patients with Coronary Heart Disease

A A Panteleeva  1   2 , N D Razgildina  3 , I A Pobozheva  3   4 , E A Polyakova  4 , K V Dracheva  3 , O D Belyaeva  4 , O A Berkovich  4 , E I Baranova  4 , S N Pchelina  3   4 , V V Miroshnikova  3   4
Affiliations

Expression of Genes Encoding Nuclear Factors PPARγ, LXRβ, and RORα in Epicardial and Subcutaneous Adipose Tissues in Patients with Coronary Heart Disease

A A Panteleeva et al. Bull Exp Biol Med. 2021 Mar.

Abstract

The nuclear factors PPARγ, RORα, and LXRβ are involved in transcriptional control of adipogenesis and implicated in glucose and lipid metabolism. In adipose tissues, they regulate inflammation. This study focuses on expression of the PPARG, RORA, and LXRβ (NR1H2) genes in epicardial and subcutaneous adipose tissues in patients with coronary heart disease as well as with concomitant abdominal obesity. In patients with coronary heart disease and abdominal obesity, PPARG mRNA level in subcutaneous adipose tissue was reduced in comparison with control group. In patients with total coronary occlusions, LXRβ mRNA level in epicardial adipose tissue was reduced, and it positively correlated with plasma HDL cholesterol. Thus, in cases of concomitant abdominal obesity and chronic total coronary occlusions, coronary heart disease is characterized by down-regulated expression of the genes of various transcriptional adipogenesis-regulating factors in adipose tissue.

Keywords: adipose tissue; coronary heart disease; nuclear factors.

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