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. 2021 Jan;63(1):e12217.
doi: 10.1002/1348-9585.12217.

Protective effects of vitamins/antioxidants on occupational noise-induced hearing loss: A systematic review

Milad Abbasi  1 , Behnaz Pourrajab  2 , Mohammad Osman Tokhi  3
Affiliations

Protective effects of vitamins/antioxidants on occupational noise-induced hearing loss: A systematic review

Milad Abbasi et al. J Occup Health. 2021 Jan.

Abstract

Objectives: Occupational noise-induced hearing loss (NIHL) due to industrial, military, and other job -related noise exposure can cause harmful health issues to occupied workers, but may also be potentially preventable. Vitamins/antioxidant have been studied as therapeutic strategies to prevent and/or delay the risks of human diseases as well as NIHL .So, this study was conducted to systematically review the protective effects of vitamins/antioxidants on occupational NIHL.

Methods: Online databases including PubMed/Medline, Scopus, Web of Science, EMBASE, Science Direct, and Google Scholar were systematically searched up to 12 January 2021. Based on 6336 potentially relevant records identified through the initial search in the databases, 12 full-text publications were retrieved, one of which can be viewed as two separate trials, because it has studied the effects of two different antioxidants (ginseng and NAC) on NIHL, separately.

Results: A review of the studies shows that vitamin B12, folic acid, and N-acetylcysteine (NAC) have a considerable protective effect on NIHL. However, these protective effects are not yet specified in different frequencies. The findings regarding the protective effects of other antioxidants are inconsistent in this field.

Conclusion: Vitamin B12, folic acid, and NAC may have a protective effect as an antioxidant on reducing occupational hearing loss. For a conclusive evidence of vitamin/antioxidant protective therapies, future studies with precise criteria for noise exposure and similar outcome parameters are required.

Keywords: NIHL; antioxidants; occupational noise-induced hearing loss; vitamins.

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Conflict of interest statement

Approval of the research protocol: NA. Informed consent: NA. Registry and the registration no. of the study/trial: It was not registered in PROSPERO. Animal studies: NA. Conflict of interest: The authors declare that they have no competing interests.

Figures

FIGURE 1
FIGURE 1
Flow chart of the study selection process
See this image and copyright information in PMC

References

    1. Monazzam MR, Zakerian SA, Kazemi Z, et al. Investigation of occupational noise annoyance in a wind turbine power plant. J Low Freq Noise V A. 2019;38:798‐807.
    1. Abbasi M, Tokhi MO, Falahati M, et al. Effect of personality traits on sensitivity, annoyance and loudness perception of low‐and high‐frequency noise. J Low Freq Noise V A. 2020;1461348420945818, in press.
    1. Kerns E, Masterson EA, Themann CL, Calvert GM. Cardiovascular conditions, hearing difficulty, and occupational noise exposure within US industries and occupations. Am J Ind Med 2018;61:477‐491. - PMC - PubMed
    1. Abbasi M, Farhang‐Dehghan S, Yazdanirad S, et al. Assessment of role of job components and individual parameters on the raised blood pressure in a noisy industry. Arch Acoust. 2019;44:575‐584.
    1. Nelson DI, Nelson RY, Concha‐Barrientos M, Fingerhut M. The global burden of occupational noise‐induced hearing loss. Am J Ind Med. 2005;48:446‐458. - PubMed

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