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. 1977 Dec;12(6):745-7.
doi: 10.1128/AAC.12.6.745.

Penicillins activate autolysins extracted from both Escherichia coli and Klebsiella pneumoniae envelopes

R Fontana, G Satta, C A Romanzi

Penicillins activate autolysins extracted from both Escherichia coli and Klebsiella pneumoniae envelopes

R Fontana et al. Antimicrob Agents Chemother. 1977 Dec.

Abstract

Ampicillin at a 50-mug/ml concentration effects a doubling of the autolysis rate of cell envelopes isolated from Klebsiella pneumoniae Mir A12. This antibiotic increases also by two- to threefold the depolymerizing activity of both K. pneumoniae and Escherichia coli crude extracts on a labeled peptidoglycan-lipoprotein complex. Several other penicillins also activate autolysins.

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References

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    1. Eur J Biochem. 1974 Jan 3;41(1):203-8 - PubMed
    1. Eur J Biochem. 1974 Feb 1;41(3):457-63 - PubMed
    1. J Bacteriol. 1974 Feb;117(2):578-87 - PubMed
    1. J Gen Microbiol. 1974 Jan;80(1):65-75 - PubMed

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