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. 2021 Mar 31;11(1):7310.
doi: 10.1038/s41598-021-86853-4.

Risk factors on admission associated with hospital length of stay in patients with COVID-19: a retrospective cohort study

Anping Guo #  1 , Jin Lu #  1 , Haizhu Tan #  2 , Zejian Kuang  3 , Ying Luo  4 , Tian Yang  4 , Junlan Xu  4 , Jishuang Yu  4 , Canhong Wen  5 , Aizong Shen  6
Affiliations

Risk factors on admission associated with hospital length of stay in patients with COVID-19: a retrospective cohort study

Anping Guo et al. Sci Rep. .

Abstract

Treating patients with COVID-19 is expensive, thus it is essential to identify factors on admission associated with hospital length of stay (LOS) and provide a risk assessment for clinical treatment. To address this, we conduct a retrospective study, which involved patients with laboratory-confirmed COVID-19 infection in Hefei, China and being discharged between January 20 2020 and March 16 2020. Demographic information, clinical treatment, and laboratory data for the participants were extracted from medical records. A prolonged LOS was defined as equal to or greater than the median length of hospitable stay. The median LOS for the 75 patients was 17 days (IQR 13-22). We used univariable and multivariable logistic regressions to explore the risk factors associated with a prolonged hospital LOS. Adjusted odds ratios (aORs) and 95% confidence intervals (CIs) were estimated. The median age of the 75 patients was 47 years. Approximately 75% of the patients had mild or general disease. The univariate logistic regression model showed that female sex and having a fever on admission were significantly associated with longer duration of hospitalization. The multivariate logistic regression model enhances these associations. Odds of a prolonged LOS were associated with male sex (aOR 0.19, 95% CI 0.05-0.63, p = 0.01), having fever on admission (aOR 8.27, 95% CI 1.47-72.16, p = 0.028) and pre-existing chronic kidney or liver disease (aOR 13.73 95% CI 1.95-145.4, p = 0.015) as well as each 1-unit increase in creatinine level (aOR 0.94, 95% CI 0.9-0.98, p = 0.007). We also found that a prolonged LOS was associated with increased creatinine levels in patients with chronic kidney or liver disease (p < 0.001). In conclusion, female sex, fever, chronic kidney or liver disease before admission and increasing creatinine levels were associated with prolonged LOS in patients with COVID-19.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
Creatinine level during hospitalization period until 15 days.
See this image and copyright information in PMC

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