DNA-based screening and personal health: a points to consider statement for individuals and health-care providers from the American College of Medical Genetics and Genomics (ACMG)

Lora J H Bean¹, Maren T Scheuner^{2

3}, Michael F Murray⁴, Leslie G Biesecker⁵, Robert C Green^{6

7

8}, Kristin G Monaghan⁹, Glenn E Palomaki^{10

11}, Richard R Sharp¹², Tracy L Trotter¹³, Michael S Watson¹⁴, Cynthia M Powell^{15

16}; ACMG Board of Directors

Affiliations

¹ Department of Human Genetics, Emory University, Atlanta, GA, USA.
² Division of Medical Genetics, Department of Pediatrics, and Division of Hematology-Oncology, Department of Medicine, University of California San Francisco School of Medicine, San Francisco, CA, USA.
³ Clinical Genetics Program, San Francisco VA Health Care System, San Francisco, CA, USA.
⁴ Department of Genetics, Yale School of Medicine, New Haven, CT, USA.
⁵ Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
⁶ Harvard Medical School, Boston, MA, USA.
⁷ Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
⁸ The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
⁹ GeneDx, Gaithersburg, MD, USA.
¹⁰ Department of Pathology and Laboratory Medicine, Alpert Medical School, Brown University, Providence, RI, USA.
¹¹ Women and Infants Hospital, Providence, RI, USA.
¹² Biomedical Ethics Program, Mayo Clinic, Rochester, MN, USA.
¹³ San Ramon Valley Primary Care Medical Group, San Ramon, CA, USA.
¹⁴ Self-employed, Washington, DC, USA.
¹⁵ Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
¹⁶ Division of Genetics and Metabolism, Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Free article

Lora J H Bean et al. Genet Med. 2021 Jun.

Free article

. 2021 Jun;23(6):979-988.

doi: 10.1038/s41436-020-01083-9. Epub 2021 Mar 31.

¹ Department of Human Genetics, Emory University, Atlanta, GA, USA.
² Division of Medical Genetics, Department of Pediatrics, and Division of Hematology-Oncology, Department of Medicine, University of California San Francisco School of Medicine, San Francisco, CA, USA.
³ Clinical Genetics Program, San Francisco VA Health Care System, San Francisco, CA, USA.
⁴ Department of Genetics, Yale School of Medicine, New Haven, CT, USA.
⁵ Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
⁶ Harvard Medical School, Boston, MA, USA.
⁷ Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
⁸ The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
⁹ GeneDx, Gaithersburg, MD, USA.
¹⁰ Department of Pathology and Laboratory Medicine, Alpert Medical School, Brown University, Providence, RI, USA.
¹¹ Women and Infants Hospital, Providence, RI, USA.
¹² Biomedical Ethics Program, Mayo Clinic, Rochester, MN, USA.
¹³ San Ramon Valley Primary Care Medical Group, San Ramon, CA, USA.
¹⁴ Self-employed, Washington, DC, USA.
¹⁵ Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
¹⁶ Division of Genetics and Metabolism, Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

No abstract available

Comment in

From genes to public health: are we ready for DNA-based population screening?
Khoury MJ, Dotson WD. Khoury MJ, et al. Genet Med. 2021 Jun;23(6):996-998. doi: 10.1038/s41436-021-01141-w. Epub 2021 Mar 31. Genet Med. 2021. PMID: 33790422 Free PMC article. No abstract available.

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