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. 2021 Apr;19(4):1112-1115.
doi: 10.1111/jth.15222.

Definition of haemostatic effectiveness in interventions used to treat major bleeding: Communication from the ISTH SSC Subcommittee on Control of Anticoagulation

Nakisa Khorsand  1 , Jan Beyer-Westendorf  2 , Ravi Sarode  3 , Sam Schulman  4   5 , Karina Meijer  6
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Free article

Definition of haemostatic effectiveness in interventions used to treat major bleeding: Communication from the ISTH SSC Subcommittee on Control of Anticoagulation

Nakisa Khorsand et al. J Thromb Haemost. 2021 Apr.
Free article
No abstract available

Keywords: DOAC reversal; anticoagulant reversal; bleeding management; hemostatic effectiveness; major bleed.

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References

REFERENCES

    1. Khorsand N, Majeed A, Sarode R, Beyer-Westendorf J, Schulman S, Meijer K. Assessment of effectiveness of major bleeding management: proposed definitions for effective hemostasis: communication from the SSC of the ISTH. J Thromb Haemost. 2016;14(1):211-214.
    1. Sheikh-Taha M. Treatment of apixaban- and rivaroxaban-associated major bleeding using 4-factor prothrombin complex concentrate. Intern Emerg Med. 2018;14(2):265-269. https://doi.org/10.1007/s11739-018-1977-9.
    1. Piran S, Khatib R, Schulman S, et al. Management of direct factor Xa inhibitor-related major bleeding with prothrombin complex concentrate: a meta-analysis. Blood Adv. 2019;3:158-167. https://doi.org/10.1182/bloodadvances.2018024133.
    1. Arachchillage DRJ, Alavian S, Griffin J, et al. Efficacy and safety of prothrombin complex concentrate in patients treated with rivaroxaban or apixaban compared to warfarin presenting with major bleeding. Br J Haematol. 2019;184(5):808-816.
    1. Majeed A, Ågren A, Holmström M, et al. Management of rivaroxaban- or apixaban-associated major bleeding with prothrombin complex concentrates: a cohort study. Blood. 2017;130:1706-1712. https://doi.org/10.1182/blood-2017-05-782060.

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