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Review
. 2021 Apr 1;11(2):1679-1730.
doi: 10.1002/cphy.c200007.

Neuroendocrine Peptides of the Gut and Their Role in the Regulation of Food Intake

Martha A Schalla  1 , Yvette Taché  2   3 , Andreas Stengel  1   4
Affiliations
Review

Neuroendocrine Peptides of the Gut and Their Role in the Regulation of Food Intake

Martha A Schalla et al. Compr Physiol. .

Abstract

The regulation of food intake encompasses complex interplays between the gut and the brain. Among them, the gastrointestinal tract releases different peptides that communicate the metabolic state to specific nuclei in the hindbrain and the hypothalamus. The present overview gives emphasis on seven peptides that are produced by and secreted from specialized enteroendocrine cells along the gastrointestinal tract in relation with the nutritional status. These established modulators of feeding are ghrelin and nesfatin-1 secreted from gastric X/A-like cells, cholecystokinin (CCK) secreted from duodenal I-cells, glucagon-like peptide 1 (GLP-1), oxyntomodulin, and peptide YY (PYY) secreted from intestinal L-cells and uroguanylin (UGN) released from enterochromaffin (EC) cells. © 2021 American Physiological Society. Compr Physiol 11:1679-1730, 2021.

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References

    1. Abbott CR, Small CJ, Kennedy AR, Neary NM, Sajedi A, Ghatei MA, Bloom SR. Blockade of the neuropeptide Y Y2 receptor with the specific antagonist BIIE0246 attenuates the effect of endogenous and exogenous peptide YY(3-36) on food intake. Brain Res 1043: 139-144, 2005.
    1. Abizaid A, Liu ZW, Andrews ZB, Shanabrough M, Borok E, Elsworth JD, Roth RH, Sleeman MW, Picciotto MR, Tschöp MH, Gao XB, Horvath TL. Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite. J Clin Invest 116: 3229-3239, 2006.
    1. Abraham MA, Lam TKT. Glucagon action in the brain. Diabetologia 59: 1367-1371, 2016.
    1. Acar S, Çatli G, Küme T, Tuhan H, Gürsoy Çalan Ö, Demir K, Böber E, Abaci A. Increased concentrations of serum nesfatin-1 levels in childhood with idiopathic chronic malnutrition. Turk J Med Sci 48: 378-385, 2018.
    1. Adachi S, Takiguchi S, Okada K, Yamamoto K, Yamasaki M, Miyata H, Nakajima K, Fujiwara Y, Hosoda H, Kangawa K, Mori M, Doki Y. Effects of ghrelin administration after total gastrectomy: A prospective, randomized, placebo-controlled phase II study. Gastroenterology 138: 1312-1320, 2010.

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