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Case Reports
. 2021 Mar;39(1):72-77.
doi: 10.3857/roj.2020.00591. Epub 2021 Mar 30.

Clinical behaviour and outcome in pediatric glioblastoma: current scenario

Aditya Kumar Singla  1 , Renu Madan  1 , Kirti Gupta  2 , Shikha Goyal  1 , Narendra Kumar  1 , Sushant Kumar Sahoo  3 , Deepak K Uppal  1 , Chirag K Ahuja  4
Affiliations
Case Reports

Clinical behaviour and outcome in pediatric glioblastoma: current scenario

Aditya Kumar Singla et al. Radiat Oncol J. 2021 Mar.

Abstract

Pediatric glioblastoma (pGBM) is a rare entity accounting for only approximately 3% of all childhood brain tumors. Treatment guidelines for pGBM have been extrapolated from those in adult glioblastoma. Rarity of pGBM and underrepresentation of pediatric population in major studies precludes from defining the ideal treatment protocol for these patients. Maximum safe resection is performed in most of the cases followed by postoperative radiotherapy in children over 3 years of age. Benefit of temozolomide is unclear in these patients. Here, we present the clinicopathological details and outcome of six pGBM patients treated at our institute in 2018-2019.

Keywords: Child; Genetics; Glioblastoma; Radiotherapy; Temozolomide.

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Conflict of interest statement

Conflict of Interest

No potential conflict of interest relevant to this article was reported.

Figures

Fig. 1.
Fig. 1.
(A) Low magnification showing tumor cells dispersed in sheets separated by areas of palisading necrosis (H&E, ×100). (B) Markedly pleomorphic cells dispersed in sheets against a fibrillary background (H&E ×200). (C) Many bizarre cells including tumor giant cells are seen. Mitoses was readily identified (H&E, ×200). (D) High magnification depicting tumor giant cells with scattered apoptotic bodies (H&E, ×400).
Fig. 2.
Fig. 2.
(A) Tumor cells negative for IDH1 R132H mutant protein (immunoperoxidase, ×400). (B) Tumor cells show loss of nuclear expression of ATRX (mutant phenotype) (immunoperoxidase, ×200). (C) Strong and diffuse immunopositivity for p53 protein (mutant phenotype) (immunoperoxidase, ×200). (D) Tumor cells show retained expression of H3K27me3 indicating absence for H2K37M mutant protein (immunoperoxidase, ×200).
Fig. 3.
Fig. 3.
CT/MRI fusion at the time of radiotherapy planning is showing large residual disease in case 4. Entire T2 signal abnormality on MRI along with post-operative cavity was included in GTV. A margin of 2 cm was given to GTV to create CTV. Further a margin of 0.5 cm was given to CTV to create planning target volume. CT, computed tomography; MRI, magnetic resonance imaging; GTV, gross tumor volume; CTV, clinical target volume.
See this image and copyright information in PMC

References

    1. Ostrom QT, Gittleman H, Liao P, et al. CBTRUS statistical report: primary brain and central nervous system tumors diagnosed in the United States in 2007-2011. Neuro Oncol. 2014;16 Suppl 4(Suppl 4):iv1–63. - PMC - PubMed
    1. Ostrom QT, Gittleman H, Fulop J, et al. CBTRUS statistical report: primary brain and central nervous system tumors diagnosed in the United States in 2008-2012. Neuro Oncol. 2015;17 Suppl 4(Suppl 4):iv1–iv62. - PMC - PubMed
    1. Nikitovic M, Stanic D, Pekmezovic T, et al. Pediatric glioblastoma: a single institution experience. Childs Nerv Syst. 2016;32:97–103. - PubMed
    1. Sgouros S, Fineron PW, Hockley AD. Cerebellar astrocytoma of childhood: long-term follow-up. Childs Nerv Syst. 1995;11:89–96. - PubMed
    1. Malik N, Kumar R, Prasad KN, Kawal P, Srivastava A, Mahapatra AK. Association of matrix metalloproteinase-1 gene polymorphism with glioblastoma multiforme in a northern Indian population. J Neurooncol. 2011;102:347–52. - PubMed

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