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Meta-Analysis
. 2021 Mar;35(3):245-251.
doi: 10.13201/j.issn.2096-7993.2021.03.012.

[A Meta-analysis of risk factors related to the lymph nodes posterior to the right recurrent laryngeal nerve in thyroid micropapillary carcinoma]

[Article in Chinese]
Huifang Wang  1 , Bo Yu  1 , Wenjun Zhao  1 , Jing Liu  2
Affiliations
Meta-Analysis

[A Meta-analysis of risk factors related to the lymph nodes posterior to the right recurrent laryngeal nerve in thyroid micropapillary carcinoma]

[Article in Chinese]
Huifang Wang et al. Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2021 Mar.

Abstract
in English, Chinese

Objective:To evaluate the risk factors for metastasis of the lymph nodes posterior to the right recurrent laryngeal nerve in thyroid micropapillary carcinoma（PTMC） by Meta-analysis. Methods:We searched domestic and foreign databases for relevant studies published up to June, 2020. Two independent reⅥewers performed literature screening and data extraction according to the inclusion and exclusion criteria. Then, Meta-analysis was performed using Revman 5.3 software. Results:A total of 5 articles were included, with a total of 1884 subjects.The results of the study showed that the rate of lymph node metastasis in PTMC Ⅵb area was 10.8% （203/1884）. The risk factors for metastasis included patients' age <45 years old, male, right lobe tumor Diameter ≥0.5 cm, invading the envelope, Ⅵa lymph node metastasis. Conclusion:Ⅵb lymph node dissection is recommended when there exists age<45 years, male sex, right lobe tumor≥0.5 cm, capsular invasion or Ⅵa lymph node metastasis.

目的：通过Meta分析探讨甲状腺微小乳头状癌（PTMC）右侧喉返神经后方（Ⅵb区）淋巴结转移的危险因素。 方法：检索国内外文献数据库中PTMC喉返神经后方淋巴结转移相关的文献，检索截止时间是2020年6月，由两名研究者筛选文献、提取数据后，采用Revman5.3软件进行Meta分析。 结果：共纳入5篇文章，共计1884例研究对象，研究结果显示：PTMC Ⅵb区淋巴结转移率为10.8%（203/1884），转移危险因素包括患者年龄<45岁，男性，右叶肿瘤直径≥0.5 cm，侵出包膜，Ⅵa淋巴结转移。 结论：对PTMC有Ⅵb区淋巴结转移高危因素的患者应该行包含Ⅵb区淋巴结在内彻底的淋巴结清扫。.

Keywords: Meta-analysis; lymphatic metastasis; neck dissection; recurrent laryngeal nerve; thyroid neoplasms.

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Conflict of interest statement

The authors of this article and the planning committee members and staff have no relevant financial relationships with commercial interests to disclose.

Figures

图 1
图 1
文献筛选流程图
图 2
图 2
PTMC患者性别与Ⅵb区淋巴结转移相关性Meta分析森林图
图 3
图 3
PTMC患者年龄与Ⅵb区淋巴结转移相关性Meta分析森林图
图 4
图 4
PTMC患者右侧肿瘤直径与Ⅵb区淋巴结转移相关性Meta分析森林图
图 5
图 5
PTMC患者肿瘤位置与Ⅵb区淋巴结转移相关性Meta分析森林图
图 6
图 6
PTMC患者肿瘤侵出包膜与Ⅵb区淋巴结转移相关性Meta分析森林图
图 7
图 7
PTMC患者肿瘤腺外侵犯与Ⅵb区淋巴结转移相关性Meta分析森林图
图 8
图 8
PTMC患者多灶性与Ⅵb区淋巴结转移相关性Meta分析森林图
图 9
图 9
PTMC合并桥本甲状腺炎与Ⅵb区淋巴结转移相关性Meta分析森林图
图 10
图 10
PTMC Ⅵa区淋巴结转移与Ⅵb区淋巴结转移相关性Meta分析森林图
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