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. 2021 Apr;14(2):e003262.
doi: 10.1161/CIRCGEN.120.003262. Epub 2021 Apr 2.

Concordance of a High Polygenic Score Among Relatives: Implications for Genetic Counseling and Cascade Screening

Nicholas J Reid  1   2 , Deanna G Brockman  3   1 , Courtney Elisabeth Leonard  3   1 , Renee Pelletier  3   1 , Amit V Khera  3   1   2
Affiliations

Concordance of a High Polygenic Score Among Relatives: Implications for Genetic Counseling and Cascade Screening

Nicholas J Reid et al. Circ Genom Precis Med. 2021 Apr.
No abstract available

Keywords: cognition; genetics; humans; obesity; phenotype.

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Figures

Figure.
Figure.
Concordance of polygenic scores among related individuals. Two-dimensional correlation heat maps of polygenic scores for coronary artery disease (CAD) between pairs of monozygotic twins (A), siblings (B), and second-degree relatives (C). D, The percentage of individuals with a sibling’s polygenic score above a certain threshold percentage who also share a similarly increased polygenic score for 4 cardiometabolic diseases. Polygenic scores were normalized to have a mean of 0 and SD of 1 as performed previously.– Among sibling pairs with discordant disease status, median polygenic score was higher in the afflicted siblings for each of the 4 diseases, with effect ranging from 0.22 to 0.44 SD units (P<0.001 by paired Wilcoxon rank-sum test for each; E).
See this image and copyright information in PMC

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