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Review
. 2021 Mar;35(2):101515.
doi: 10.1016/j.beem.2021.101515. Epub 2021 Mar 10.

Osteopathy in mild adrenal Cushing's syndrome and Cushing disease

Stefano Frara  1 , Agnese Allora  1 , Luigi di Filippo  1 , Anna Maria Formenti  1 , Paola Loli  1 , Elisabetta Polizzi  2 , Daniele Tradati  3 , Fabio Massimo Ulivieri  1 , Andrea Giustina  4
Affiliations
Review

Osteopathy in mild adrenal Cushing's syndrome and Cushing disease

Stefano Frara et al. Best Pract Res Clin Endocrinol Metab. 2021 Mar.

Abstract

Pathophysiology and effects of endogenous glucocorticoid (GC) excess on skeletal endpoints as well as awareness and management of bone fragility are reviewed. Cushing's syndrome (CS) increase the risk of fracture affecting prevalently bone quality. Bone antiresorptive agents (SERMs, bisphosphonates and denosumab) as well as teriparatide increase bone mineral density and in some instances reduce fracture risk. Awareness and management of bone health in CS can be improved.

Keywords: adrenal incidentaloma; bone mineral density; bone quality; cushing disease; fractures; glucocorticoids.

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